CD28− T cells: their role in the age-associated decline of immune function

By N. Weng, A. Akbar, J. Goronzy. Trends in immunology, 2009

626 citations recorded by the source corpus.

Summary The accumulation of CD28− T cells, particularly within the CD8 subset, is one of the most prominent changes during T cell homeostasis and function associated with aging in human. CD28, a major co-stimulatory receptor, is responsible for the optimal antigen-mediated T cell activation, proliferation, and survival of T cells. CD28− T cells exhibit reduced antigen receptor diversity, defective antigen-induced proliferation, and a shorter replicative lifespan while showing enhanced cytotoxicity and regulatory functions. Gene expression analyses reveal profound changes of CD28− T cells in comparison to their CD28+ counterparts and support their functional differences. Here we review the recent advance of our understanding of CD28− T cells and their role in age-associated decline of immune function.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/8a1c0014563eb872e1424c59d8573133991e8c11

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In Immunology

Citations in the corpus

DNA methylation and healthy human aging (2015, background): “as the relative frequencies of white blood cells change over the lifespan (Weng et al., 2009; Jaffe & Irizarry, 2014).”
Rescue of exhausted CD8 T cells by PD-1 targeted therapies is CD28-dependent (2017, background): “In humans, antigenexperienced CD8 T cells can lose CD28 expression, and loss of CD28 has been associated with chronic stimulation (18).”
Metabolic Regulation of T Lymphocytes (2013, background): “Aside from inhibitory receptors, downregulation of the costimulatory receptor CD28 itself is also observed following repetitive stimulation and in aged individuals (109), and this may contribute to reduced T cell activity in these cases.”