c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

By Marius Wernig, Alexander Meissner, John P. Cassady, R. Jaenisch. Cell Stem Cell, 2008

655 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/31c31c26c803882102d22b4a790a046c463849b9

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Citations in the corpus

Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. (2008, background): “Omission of c-Myc from the reprogramming cocktail further reduces the efficiency and delays the process (Nakagawa et al., 2008; Wernig et al., 2008).”
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 (2008, positive): “Through optimization of the reprogramming method, it is now possible to reprogram both mouse and human somatic cells with the three-factor combination of OCT4 , SOX2 and KLF4 , without the potent oncogene c-MYC”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “Only a subset of fibroblasts expressing reprogramming factors down-regulates somatic markers and activates pluripotency genes (Wernig et al. 2008a; Stadtfeld et al. 2010a), indicating that many cells are refractory to reprogramming or become so as a consequence of factor expression.”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “iPS are relatively indistinguishable from ES as morphology, growth ability, chromatin state, gene expression profiling, and potential to differentiate into any cell type (137, 165, 239).”
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy (2011, background): “Most importantly, even with three-factor transduction, the first contracting patches emerge within 12 days, a much shorter period than the approximately three-week minimum required to generate iPSCs with three factor”
Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009, background): “Although reprogramming has been achieved in the absence of c-MYC, though with longer latency and substantially reduced efficiency (Nakagawa et al., 2008; Wernig et al., 2008), the remaining integrated reprogramming factors could also cause tumor formation (Hochedlinger et al., 2005).”
The tumorigenicity of human embryonic and induced pluripotent stem cells (2011, background): “, and many of the four-gene iPSC mice chimaeras died from cancer within the first few months of their live”
Nuclear reprogramming to a pluripotent state by three approaches (2010, background): “Subsequent studies showed that iPS cells could be generated without overexpressing c-MY”
A combined chemical and genetic approach for the generation of induced pluripotent stem cells. (2008, neutral): “Recent studies have shown that c-Myc, one of the four genes originally thought to be required for iPS cell generation, is dispensable, but in its absence the reprogramming efficiency is reduced (Nakagawa et al., 2008; Wernig et al., 2008).”
An extended transcriptional network for pluripotency of embryonic stem cells. (2008, background): “This unique target regulation by Myc may account for its capacity to enhance reprogramming, while also being dispensable as an exogenous factor (Nakagawa et al., 2007; Wernig et al., 2007a).”