Redox Regulation of Forkhead Proteins Through a p66shc-Dependent Signaling Pathway

By S. Nemoto, Toren Finkel. Science, 2002

879 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/319b4c7b09d830a28d8f848d8f8816c795d473a0

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Citations in the corpus

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. (2007, background): “In addition, the oxidative stress response is regulated in part by FoxO induction of MnSOD, catalase, and GADD45 (Kops et al., 2002a; Nemoto and Finkel, 2002; Tran et al., 2002), and has been linked to longevity and dauer formation in C. elegans (Honda and Honda, 1999; Lee et al., 2003; Murphy et…”
Mitochondrial reactive oxygen species and cancer (2014, background): “PP2A dephosphorylates Akt on threonine 308 and serine 493 resulting in Akt inactivation; however, PP2A dephosphorylation activity is inhibited by hydrogen peroxide [41].”
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging (2011, neutral): “[168, 169].”
Reperfusion injury and reactive oxygen species: The evolution of a concept (2015, neutral): “scriptional upregulation of antioxidant enzymes [357].”
FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “In addition, FOXO proteins have been reported to allow detoxification of reactive oxygen species (ROS) by upregulating the free radical scavenging enzymes, including Mn superoxide dismutase (MnSOD) and catalase (Kops et al., 2002a; Nemoto and Finkel, 2002; Ramaswamy et al., 2002; Tran et al., 2002).”
Signal transduction by reactive oxygen species (2011, background): “In addition, certain long-lived mouse models such as deletion of the p66shc gene appear to extend life by modulating ROS levels (Migliaccio et al., 1999; Nemoto and Finkel, 2002; Giorgio et al., 2005).”
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “Furthermore, Nemoto and Finkel (185) have identified a pathway for peroxide modulation of the Forkhead protein in p66shc null mice fibroblasts and Migliaccio et al.”
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. (2006, background): “The promoters with a mutation in the FOXO3A, MAD box transcription enhancer factor (MEF), or NRF2 sites displayed the same activity as the control promoter in the absence or presence of H2O2 (Figure 3A).”
Reactive oxygen species in tumor progression. (2005, background): “Guyton, K. Z., Y. Liu, M. Gorospe, Q. Xu & N. J. Holbrook: Activation of mitogen-activated protein kinase by H2O2.”
ATM Activation by Oxidative Stress (2010, background): “elegans, H2O2 negatively regulates the activity of forkhead proteins in a p66shc-dependent way [133] .”