Intronic microRNA precursors that bypass Drosha processing

By J. Ruby, Calvin H. Jan, David P. Bartel. Nature, 2007

1,672 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/30a64a5994f6216a5f46ab820b17208a83e126a7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

Biogenesis of small RNAs in animals (2009, background): “Apart from canonical intronic miRNAs, small groups of miRNA-like RNAs have been discovered in introns in flies and mammal”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “…was then found to block accumulation of mature let-7 by repression of both Drosha and Dicer activities (Heo et al., 2008; Newman et al., 2008; Rybak et al., 2008; Viswanathan et al., 2008), recent studies demonstrate that LIN-28 can induce 30 terminal uridylation of pre-let-7 miRNA in mouse…”
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. (2007, positive): “On the other hand, most mirtrons are preserved only within species of the melanogaster subgroup (D. melanogaster, D. simulans/ sechellia, and/or D. yakuba/erecta), suggesting that they were born within the last 5–10 million years (Figures 2B and S1; Ruby et al., 2007).”
Genetic variation in microRNA networks: the implications for cancer research (2010, positive): “Furthermore, an alternative miRNA processing pathway has been uncovered in both Drosophila melanogaster and Caenorhabditis elegans that bypasses DROSHA and instead uses a splicing technique to generate miRNA precursors from short intronic sequences (mirtrons”
MicroRNAs in development and disease. (2011, background): “Alternatively, a few intronic pri-miRNAs (mirtrons) bypass Drosha/DGCR8 and are processed by the splicing machinery (34, 516).”
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. (2008, background): “The dependence of these reads on Dicer but not DGCR8 extended demonstration of enzymatic requirements for mirtron biogenesis beyond flies to mammals (Okamura et al. 2007; Ruby et al. 2007a), thereby confirming the proposal that mammals have mirtrons (Berezikov et al.”
Small RNA sorting: matchmaking for Argonautes (2010, background): “For example, mirtrons have been found in flies and mammal”
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. (2007, background): “Mirtronic loci are described elsewhere (Ruby et al. 2007).”
Metazoan MicroRNAs (2018, background): “In contrast to the other known noncanonical miRNAs, which require Dicer but not Drosha for their biogenesis (Figure 3B–”
Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs. (2009, background): “However, mirtrons, miRNAs located in small introns, bypass this process and are generated by splicing (Berezikov et al. 2007; Okamura et al. 2007; Ruby et al. 2007).”
Small non-coding RNAs in animal development (2008, background): “Independently of Drosha, a subset of pre-miRNA hairpins can also be generated from introns by the combined actions of the spliceosome and the lariat-debranching enzyme (LDBR”