Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs.

By Christian Cole, Andrew Sobala, Cheng Lu, Shawn Thatcher, A. Bowman, John W. S. Brown, Pamela J. Green, Geoffrey J. Barton, Gyorgy Hutvagner. RNA: A publication of the RNA Society, 2009

622 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b29ec9e69924854808c4b41bb5334885a5b5748a

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Citations in the corpus

• RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage. (2010, background): “Defined tRNA fragments have been identified through small RNA cloning approaches (Kawaji et al. 2008; Cole et al. 2009; Haussecker et al. 2010), suggesting a physiological role for tRNA fragments.”
• Landscape of transcription in human cells (2012, neutral): “Whereas subfragments of mature tRNAs have been reported previously, these reports were confined to distinct alleles of only a few tRNA genes 26–28 .”
• Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “Some small nucleolar RNAs (snoRNAs), transfer RNAs (tRNAs), and endogenous short hairpin RNAs (shRNAs) are also processed into miRNA-like molecules independently of the Microprocessor complex (Babiarz et al., 2008; Ender et al., 2008; Saraiya and Wang 2008; Cole et al., 2009).”
• Bacterial small RNA regulators: versatile roles and rapidly evolving variations. (2011, result): “This prediction is supported by recent studies in eukaryotic cells (Cole et al. 2009; Lee et al. 2009; Thompson and Parker 2009); investigations of functions for tRNA fragments in bacteria have not yet been reported.”
• Human tRNA-derived small RNAs in the global regulation of RNA silencing. (2010, background): “Careful bioinformatic analyses, however, have started to reveal that some of the small RNAs derived from abundant noncoding RNAs, particularly tRNAs, are the product of specific processing by endonucleases such as Dicer (Babiarz et al. 2008; Cole et al. 2009).”
• Angiogenin-induced tRNA fragments inhibit translation initiation (2011, background): “Constitutive tRNA-derived 19–22 nucleotide ncRNAs are products of DICER (Cole et al., 2009) and the tRNA 30 end processing enzyme RNase Z (Haussecker et al.”