The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila.

By K. Okamura, Joshua W. Hagen, Hong Duan, D. Tyler, Eric C. Lai. Cell, 2007

1,114 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4cbb279288be78e91302a865ec70c08d61b0dd7d

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Citations in the corpus

Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “Recent deep-sequencing efforts, however, indicate that a large number of miRNA*s are not degraded, but rather associate with AGO1 or AGO2 (Czech et al., 2009; Ghildiyal et al., 2010; Okamura et al., 2008, 2009; Seitz et al., 2008).”
Evolution and Functional Diversification of MIRNA Genes (2011, background): “Although loop-distal processing occurs first during miRNA maturation of most foldbacks in plants and animals, alternative primary processing events have been characterized (Okamura et al., 2007; Ruby et al., 2007; Addo-Quaye et al., 2009; Bologna et al., 2009; Cheloufi et al., 2010; Cifuentes et al.”
Circular intronic long noncoding RNAs. (2013, background): “It is becoming increasingly apparent that intronic sequences are able to encode functional ncRNAs, including both small and long ncRNAs (Kiss and Filipowicz, 1995; Ladewig et al., 2012; Okamura et al., 2007; Petfalski et al., 1998; Rearick et al., 2011; Yin et al., 2012).”
The Genetic Signatures of Noncoding RNAs (2009, background): “At least some of these RNAs, including intronic RNAs, are precursors for small regulatory RNAs like microRNAs (miRNAs), small interfering RNAs (siRNAs), piwi-interacting RNAs (piRNAs), and small nucleolar RNAs (snoRNAs) [58–68].”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “mirtron transfer to the cytoplasm in some species including Xenopus laevis oocytes and Drosophila but it remains unclear whether this occurs in mammals [97, 102, 106].”
Revisiting the principles of microRNA target recognition and mode of action (2009, background): “Many animal miRNAs reside in introns, and, in some cases, splicing bypasses the Microprocessor requirement and directly produces pre-miRNA”
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. (2008, background): “A similar hp-siRNA biogenesis pathway has been reported in mouse oocytes (Tam et al. 2008; Watanabe et al. 2008) and in Drosophila (Czech et al. 2008; Ghildiyal et al. 2008; Kawamura et al. 2008; Okamura et al. 2008).”
Metazoan MicroRNAs (2018, background): “For example, certain debranched introns enter the miRNA biogenesis pathway as pre-miRNA hairpins, with their ends having been defined by the spliceosome rather than by Drosha (Okamura et al., 2007; Ruby et al., 2007a) (Figure 3B).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “In an alternative route (98), the noncanonical pathway, miRNAs are derived from short hairpin introns, named mirtrons (206).”
Mammalian mirtron genes. (2007, background): “Molecul A Plethora of Primate-Specific Mirtrons Although some are well conserved, most invertebrate mirtrons arose quite recently during Drosophilid and nematode radiation (Okamura et al., 2007; Ruby et al., 2007a); thus, the consideration of evolutionary conservation does not aid their computationa”