Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

By J. Wolfers, A. Lozier, G. Raposo, A. Régnault, C. Théry, C. Masurier, C. Flament, S. Pouzieux, F. Faure, T. Tursz and 3 more. Nature Medicine, 2001

1,603 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2f77c23d3b07ec11d8ff2b14563453a4d9c38e4f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. G. Raposo
2. C. Théry
3. Marina Colombo
4. J. Schorey
5. W. Stoorvogel
6. Benoît Février
7. Guillaume van Niel
8. Arnold J. Levine

In Molecular Biology

1. G. Raposo
2. C. Théry
3. Raghu Kalluri
4. Marina Colombo
5. S. Kourembanas
6. W. Stoorvogel
7. E. Batrakova
8. Guillaume van Niel

Citations in the corpus

• Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. (2013, background): “Many different cell types such as B cells [23], dendritic cells [25], mast cells [25], T cells [49], platelets [50], Schwann cells [34], tumor cells [51], mesenchymal stem cells [32], human embryonic kidney cell [52], various”
• Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “In another cell system, we have shown that CD63 functions in ESCRT-independent sorting to ILVs of the melanosomal protein PMEL (van Niel et al., 2011), a protein that is targeted to exosomes in melanoma cells (Wolfers et al., 2001).”
• Exosome Function: From Tumor Immunology to Pathogen Biology (2008, background): “Interestingly, tumorderived exosomes may have broader activity than previously believed as one study showed that exosomes isolated from different tumors inhibited not only syngeneic but also allogenic tumor growth, indicating that tumor-derived exosomes may harbor some common tumor antigens (47).”
• Extracellular vesicles in cancer: cell-to-cell mediators of metastasis (2016, background): “, Mart-1/MelanA) and can modulate immune responses (Wolfers et al., 2001).”
• Exosomes: composition, biogenesis and function (2002, neutral): “, tumours of haematopoietic or non-haematopoietic origi”
• Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses (2011, background): “Exosomes secreted by tumor cells (Figure 3) also represent a source of tumor antigens for capture and presentation by DCs in vitro (61).”
• The regulation of exosome secretion: a novel function of the p53 protein. (2006, background): “have proposed that exosomes may function as a tumor-antigen sampling compartment spread by tumor cells for immunosurveillance (44).”