The regulation of exosome secretion: a novel function of the p53 protein.

By Xin Yu, S. Harris, Arnold J. Levine. Cancer Research, 2006

691 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cd903d55a9e046ab7032a42305a4dc8ca202f9f0

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Citations in the corpus

The senescence-associated secretory phenotype and its physiological and pathological implications (2024, neutral): “During senescence, exosome production is dependent on the p53 targets TSAP6 (also known as metalloreductase STEAP3) and VPS32 (also known as vacuolar-sorting protein SNF7) 131 .”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “…et al. 2011), a signal that also promotes exosome secretion by oligodendrocytes (Fruhbeis et al. 2013). γ-Irradiation-induced DNA damage can also promote EV secretion by tumor cells or fibroblasts through the activation of the p53-regulated protein TSAP6 (Lespagnol et al. 2008, Yu et al. 2006).”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “The tumor suppressor protein p53 and its transcriptional target TSAP6 have been implicated in the regulation of exosome secretion (70), linked to the ESCRT-III component Chmp1A (71), illustrating potential couplings between signaling and exosome biogenesis.”
Effect of exosomal miRNA on cancer biology and clinical applications (2018, background): “Thus, the p53 pathway regulates the production of exosomes into the medium [22].”
Exosome Function: From Tumor Immunology to Pathogen Biology (2008, background): “demonstrated that exosomes function in the release of some p53-regulated extracellular proteins and that this effect stems from the upregulation of TSAP6 expression by p53 (41).”
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function (2015, background): “Moreover, Yu et al. discovered that both the tumor repressor protein p53 and its downstream effector TSAP6 could enhance exosome production [34].”
Transcriptional control of human p53-regulated genes (2008, background): “, alterations in the extracellular matrix, alterations in the cytoskeleton of cells, activation of the endosome compartment of cells with increased exosomal and endosomal activit”
Hypoxic enhancement of exosome release by breast cancer cells (2012, background): “The factors and stimuli that regulate exosome release are not fully understood, although roles have been reported for p53 [11,12], ceramide synthesis [13], calcium signalling [14], and acidosis [15].”