Extracellular vesicles in cancer: cell-to-cell mediators of metastasis

By A. Becker, B. K. Thakur, Joshua M. Weiss, Han Sang Kim, H. Peinado, D. Lyden. Cancer Cell, 2016

1,740 citations recorded by the source corpus.

Summary Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b909afa6b63084ab548658df15dbef568bd15c96

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Raghu Kalluri
2. Yibin Kang
3. Moshe Oren
4. Lin Zhang
5. Dihua Yu
6. Mina J. Bissell
7. D. Lyden
8. A. Llorente

In Molecular Biology

1. Raghu Kalluri
2. D. Lyden
3. R. Scherz-Shouval
4. Yibin Kang
5. Moshe Oren
6. H. Peinado
7. Lin Zhang
8. Dihua Yu

Citations in the corpus

• Systems Biology of Cancer Metastasis (2019, background): “…have uncovered pro-metastatic roles for exosomes via their effects on increasing vascular permeability and their priming of the resident cells of the metastatic site to create a pro-inflammatory and metabolically active niche(Becker et al., 2016; Costa-Silva et al., 2015; Schillaci et al., 2017).”
• Exosomes in cancer development, metastasis, and immunity (2019, background): “Furthermore, certain proteins or miRNAs in exosomes isolated from cancer patient plasma are associated with tumor metastasis or relapse [169, 170].”
• Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “During this process, exosomes are packed with proteins, lipids, DNAs, messenger RNAs (mRNAs), microRNAs (miRNA) and other non-coding RNAs (Becker et al., 2016; Figure 1B).”
• Current knowledge on exosome biogenesis and release (2017, background): “Interestingly, exosomes from cancer cells have been shown to promote angiogenesis, modulate the immune system and remodel the surrounding parenchymal tissue, all factors supporting tumor progression (reviewed in [13]).”
• Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers (2020, background): “Specific DAMP Molecules Are Packaged in TTDerived EVPs Because tumor-derived exosomes interact with the immune system (Becker et al., 2016), we asked whether specific proteins involved in eliciting immune responses, such as damage-associated molecular pattern (DAMP) proteins, which have key roles in”
• Tumor microenvironment complexity and therapeutic implications at a glance (2020, background): “Form therapeutic point of view, exosomes are applied as diagnostic biomarkers, therapeutic targets, or as anticancer drug-delivery vehicles [178] .”