Trophic macrophages in development and disease

By J. Pollard. Nature reviews. Immunology, 2009

1,233 citations recorded by the source corpus.

Specialized phagocytes are found in the most primitive multicellular organisms. Their roles in homeostasis and in distinguishing self from non-self have evolved with the complexity of organisms and their immune systems. Equally important, but often overlooked, are the roles of macrophages in tissue development. As discussed in this Review, these include functions in branching morphogenesis, neuronal patterning, angiogenesis, bone morphogenesis and the generation of adipose tissue. In each case, macrophage depletion impairs the formation of the tissue and compromises its function. I argue that in several diseases, the unrestrained acquisition of these developmental macrophage functions exacerbates pathology. For example, macrophages enhance tumour progression and metastasis by affecting tumour-cell migration and invasion, as well as angiogenesis.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2e75d81bef62d064c4b3dfdf9d977936cfd5751d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. J. Pollard
4. Lisa M. Coussens
5. S. Gordon
6. B. Ruffell
7. P. Italiani
8. D. Boraschi

In Molecular Biology

1. Lisa M. Coussens
2. A. Mantovani
3. J. Pollard
4. S. Gordon
5. A. Sica
6. B. Ruffell
7. R. Medzhitov
8. R. Chovatiya

Citations in the corpus

• Phagocytosis: An Immunobiologic Process. (2016, background): “Finally, increased uptake of dying tumor cells is characteristic of many malignancies (Pollard, 2009; Savill et al., 2002).”
• Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy (2011, background): “Accordingly, genetic or pharmacologic blockade of CSF1 or its receptor has been reported to decrease macrophage presence in tissues and in some experimental solid tumors, correlating with diminished tumor angiogenesis, reduced primary tumor growth, and pulmonary metastasis (1, 2).”
• From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “(124), support to hematopoiesis (125) Osteoporosis, osteopetrosis, arthritis (126)”
• Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells (2014, background): “Because macrophages are highly dependent on the colony-stimulating factor-1 (CSF-1) and CSF-1 receptor (CSF-1R) pathway for survival in most tissues (Pollard, 2009), there is significant interest in therapeutically targeting this pathway.”
• Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. (2010, background): “For example, in bone, osteoclast (the multinucleated macrophage of bone) resorption of matrix is necessary to maintain bone health (39).”
• Tumors as organs: complex tissues that interface with the entire organism (2010, neutral): “Inflammatory Response to Cancer Inflammatory cells are components of the microenvironment of normal tissues and organs, regulating various processes during development, including epithelial growth and branching and clearance of apoptotic cells (reviewed in Pollard, 2009).”
• Macrophage Polarization in Inflammatory Diseases (2014, background): “However, TAM is transformed into M2-like phenotype in the development of tumors, and NF-κB signal pathway is down-regulated [73].”
• Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine (2012, background): “Macrophage polarization and plasticity have been shown to play important roles in a diverse spectrum of disease processes [32,33].”
• Macrophages, innate immunity and cancer: balance, tolerance, and diversity. (2010, background): “Tumor-associated macrophages (TAM) are a major component of leukocytic infiltrate of tumors and have served as a paradigm for cancer-related inflammation [2,8,9].”
• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, neutral): “changes of the ECM compartment [7, 40, 41] (Fig.”
• Macrophage heterogeneity in tissues: phenotypic diversity and functions (2014, background): “Embryonic macrophages have been associated with phagocytosis of apoptotic cells in tissue remodeling and interaction with the extracellular matrix, important for general organogenesis and vasculogenesis (38).”
• Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. (2014, background): “In solid malignancies, additional chemokines such as MCP-1 or SDF-1 might support recruitment of monocytes (Pollard, 2009; Murdoch et al., 2008).”