Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue.

By Aliki Kosteli, E. Sugaru, G. Haemmerle, Jayne F. Martin, J. Lei, R. Zechner, A. Ferrante. Journal of Clinical Investigation, 2010

717 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/4d769ee3ab4f3abc73f8e912c9192918b139d5b8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Gerald I. Shulman
2. V. Samuel
3. A. Okunade
4. B. Patterson
5. Myung‐Sook Choi
6. A. Sica
7. Jun Yoshino
8. S. Klein

In Immunology

1. A. Mantovani
2. A. Sica
3. Xiangming Zou
4. Yan-Cun Liu
5. Yong-ming Yao
6. Y. Chai
7. Gerald I. Shulman
8. V. Samuel

In Physiology

1. V. Samuel
2. Gerald I. Shulman
3. Myung‐Sook Choi
4. A. Sica
5. Jun Yoshino
6. A. Mantovani
7. U. Jung
8. Haiming Cao

Citations in the corpus

• Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “Furthermore, it has been suggested that ATMs could mediate the removal of extracellular lipids from adipose tissues (191).”
• Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease (2014, background): “Obesity-induced increases in lipolysis not only increases local extracellular lipid concentrations but also derives accumulation of macrophages in adipose tissue [64], which is associated with systemic hyperinsulinemia and insulin resistance in obese subjects [65].”
• Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links (2012, positive): “Calorie restriction in fat-fed mice acutely increases ATMs and may represent a response to the initial increase in ATGL-mediated lipolysis (Kosteli et al., 2010).”
• Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity. (2016, result): “This biphasic adipose tissue immune response to weight loss observed in our subjects is consistent with the early increase and subsequent decrease in adipose tissue macrophage content observed after calorie restriction and weight loss in obese mice (Kosteli et al., 2010).”
• Macrophage Polarization in Inflammatory Diseases (2014, background): “Those cells might play an essential role in lipolysis and tissue homeostasis by preventing inflammation and promoting insulin sensitivity [60].”
• Macrophage plasticity and polarization: in vivo veritas. (2012, positive): “Weight loss is associated with an increase in F4/80+CD11c–CD301+ M2-like macrophages, which promote lipolysis (109).”
• What We Talk About When We Talk About Fat (2014, neutral): “During fasting and weight loss, macrophages become recruited to the fat pad by the products of lipolysis, where they are responsible for taking up the newly available lipids (Granneman et al., 2005; Kosteli et al., 2010).”
• Adipocytokines in Obesity and Metabolic Disease (2014, neutral): “2011), and lipolysis during fasting recruits macrophages that buffer local lipid increase and protect adipose function (Kosteli et al. 2010).”