Macrophages, innate immunity and cancer: balance, tolerance, and diversity.

By A. Mantovani, A. Sica. Current Opinion in Immunology, 2010

1,468 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/03f11a031c7fdb8b74bffd1df99b676a8fc05d1e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. M. Karin
3. A. Mantovani
4. O. Takeuchi
5. F. Balkwill
6. R. Medzhitov
7. R. Flavell
8. Taro Kawai

Citations in the corpus

• Macrophage plasticity and polarization: in vivo veritas. (2012, neutral): “Reorienting and reshaping deranged macrophage polarization is the holy grail of macrophage therapeutic targeting (129).”
• Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. (2011, background): “These TIE2-expressing macrophages (TEMs) have features of M2-polarized tumor-associated macrophages (TAMs) (Mantovani and Sica, 2010), promote both developmental and tumor angiogenesis (Fantin et al.”
• CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3 (2011, neutral): “Among them, tumorassociated macrophages (TAMs) are the most notable migratory hematopoietic cell type (Mantovani and Sica, 2010; Solinas et al., 2009).”
• Cancer-related inflammation: common themes and therapeutic opportunities. (2012, background): “Cells of the monocyte–macrophage lineage exhibit considerable plasticity and diversity [1,4–8].”
• Immune evasion in cancer: Mechanistic basis and therapeutic strategies. (2015, positive): “CD11b F4/80 macrophages having an M2 phenotype produce high 175 levels of TGFβ, IL-10, and vascular endothelial growth factor (VEGF) and promote tumor 176 growth [28-30].”
• The polarization of immune cells in the tumour environment by TGFβ (2010, background): “During tumour progression, the gradual inhibition of NF-κB activity in TAMs correlates with their switch from an M1 to M2 phenotyp”
• CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T Cell Checkpoint Immunotherapy in Pancreatic Cancer Models (2014, positive): “TAMs are a heterogeneous population of macrophages with diverse biological activities (24-28).”
• Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor immune microenvironment (2013, background): “Substantial experimental data from clinical and pre-clinical studies indicate that tumorassociated macrophages (TAMs) promote tumor progression and metastasis (Mantovani and Sica, 2010; Qian and Pollard, 2010).”
• The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection (2010, background): “M2 macrophages are known to be important for tumor cell survival and tissue remodeling in response to inflammation, in addition to the response against helminth infectio”
• HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. (2011, background): “However, M1-TAMs may express reduced levels of TNFa (Hagemann et al., 2008; Movahedi et al., 2010) and IL-1b (Mantovani and Sica, 2010), in line with our findings.”