Macrophage heterogeneity in tissues: phenotypic diversity and functions

By S. Gordon, A. Plüddemann, Fernando Martinez Estrada. Immunological Reviews, 2014

682 citations recorded by the source corpus.

During development and throughout adult life, macrophages derived from hematopoietic progenitors are seeded throughout the body, initially in the absence of inflammatory and infectious stimuli as tissue‐resident cells, with enhanced recruitment, activation, and local proliferation following injury and pathologic insults. We have learned a great deal about macrophage properties ex vivo and in cell culture, but their phenotypic heterogeneity within different tissue microenvironments remains poorly characterized, although it contributes significantly to maintaining local and systemic homeostasis, pathogenesis, and possible treatment. In this review, we summarize the nature, functions, and interactions of tissue macrophage populations within their microenvironment and suggest questions for further investigation.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/d29023aeced20a0c8f219506e317866851a8be43

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In Immunology

Citations in the corpus

An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. (2015, background): “However, macrophages in varying tissues have different gene expression profiles [45], supporting the idea that macrophages are heterogeneous [46].”
The role of macrophages in the resolution of inflammation. (2019, background): “For almost a century, investigators have focused on the role of monocytes and macrophages in the acute response to tissue injury, where they are known to produce cytotoxic and proinflammatory mediators, clear invading microorganisms, remove apoptotic and damaged cells, and promote tumor progression ”
Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages (2015, background): “have summarized the heterogeneity, functionality, and interactions of macrophage populations within body tissues (17).”