Macrophage Polarization in Inflammatory Diseases

By Yan-Cun Liu, Xiangming Zou, Y. Chai, Yong-ming Yao. International Journal on Biological Sciences, 2014

983 citations recorded by the source corpus.

Diversity and plasticity are two hallmarks of macrophages. M1 macrophages (classically activated macrophages) are pro-inflammatory and have a central role in host defense against infection, while M2 macrophages (alternatively activated macrophages) are associated with responses to anti-inflammatory reactions and tissue remodeling, and they represent two terminals of the full spectrum of macrophage activation. Transformation of different phenotypes of macrophages regulates the initiation, development, and cessation of inflammatory diseases. Here we reviewed the characters and functions of macrophage polarization in infection, atherosclerosis, obesity, tumor, asthma, and sepsis, and proposed that targeting macrophage polarization and skewing their phenotype to adapt to the microenvironment might hold great promise for the treatment of inflammatory diseases.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/cae1f2fd5785845caa42d6497361eba46a68f11d

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Citations in the corpus

• Role of Human Macrophage Polarization in Inflammation during Infectious Diseases (2018, background): “Both M1-like and M2-like macrophage subsets are involved in parasitic infections; macrophages undergo, in general, a dynamic switch toward the M2-like phenotype at later stages [71].”