Effects of adverse experiences for brain structure and function.

By Bruce S. McEwen. Biological Psychiatry, 2000

660 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/2de54ae72ea65624de22937100e748005aba24fd

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In Behavioral Neuroscience

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

How experience gets under the skin to create gradients in developmental health. (2010, background): “The stresses of daily living, as well as chronic repeated adversity, are thought to exert wear and tear on the HPA axis, leading to dysregulation (71, 72).”
The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. (2005, background): “There may, however, be a fine line between circumstances that can cause permanent damage and the conditions that lead to reversible remodeling of neurons [6,260].”
Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting (2006, background): “Glucocorticoids also act to enhance calcium currents in hippocampal pyramidal cells, which can induce dendritic remodeling, and it has been suggested that the contrasting effects of stress on hippocampal and amygdalar plasticity may be attributable to differences in the spatiotemporal dynamics of in”
The developing brain and neural plasticity: Implications for normality, psychopathology, and resilience. (2015, background): “been devoted to examining the effects that stress and adversity exert on the brain and neuroendocrine and immunological systems (for reviews, see Granger, Dreschel, & Shirtcliff, 2003; Gunnar, 1998; Kaufman, Plotsky, Nemeroff, & Charney, 2000; Kiecolt-Glaser, McGuire, Robles, & Glaser, 2002; Ladd et”
Cognitive Deficits in Depression and Functional Specificity of Regional Brain Activity (2007, background): “McEwen (2000) hypothesized that individuals who are more reactive to stress will be repeatedly exposed to more cortisol, leading to a progression of neuronal structural changes that could have deleterious effects on cognition such as atrophy and permanent neuronal loss.”
Structural plasticity associated with exposure to drugs of abuse. (2004, neutral): “…1995; Kolb and Whishaw, 1998; Lamprecht and LeDoux, 2004), longterm potentiation (Andersen and Soleng, 1998; Yuste and Bonhoeffer, 2001), stress (McEwen, 2000; Vyas et al., 2002), environmental manipulations (Greenough et al., 1990; van Praag et al., 2000), recovery of function (Kolb and…”
Simulated Apoptosis/Neurogenesis Regulates Learning and Memory Capabilities of Adaptive Neural Networks (2004, background): “In mammals, the hypothalamic–pituitary–adrenal (HPA) system may play an important role in such regulation given evidence associating corticosteroid responses with significant environmental change, cognitive function and neuronal atrophy and death in the hippocampus (McEwen, 2000).”
Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression (2002, background): “Another possibility is that BDNF makes hippocampal neurons more resilient and able to oppose the effects of stress (e.g., oppose the downregulation of neurotrophic factor support, inhibit potential excitoxic damage, and block neuronal atrophy; Duman et al., 2000; McEwen, 2000; Sapolsky, 2000).”