Cognitive Deficits in Depression and Functional Specificity of Regional Brain Activity

By R. Levin, Wendy Heller, Aprajita Mohanty, J. Herrington, Gregory A. Miller. Cognitive Therapy and Research, 2007

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Major Depressive Disorder is Associated with Broad Impairments on Neuropsychological Measures of Executive Function: A Meta-Analysis and Review (2012, background): “MDD is associated with structural and functional abnormalities in PFC, including DLPFC, VLPFC, and ACC (for reviews, see Levin et al., 2007; Rogers et al., 2004), and a meta-analysis found that patients with depressive disorders had decreased DLPFC and ACC activation during a resting state…”
Retrospective recall of affect in clinically depressed individuals and controls (2009, background): “Therefore for the depressed group we hypothesised just the opposite*a greater exaggeration of NA relative to PA. Finally, because depressed individuals have less cognitive resources than healthy controls (Levin et al., 2007), we expected that they rely on heuristics to a greater extent.”
Depression: A cognitive perspective. (2019, background): “To the extent that depressed individuals do exhibit deficits in executive functioning, there is at least preliminary experimental evidence to indicate that these deficits underlie depression-related difficulties in other domains of cognitive functioning, including deficits in the domains of memory, ”