Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

By Y. Shirayama, A. C. Chen, Shin Nakagawa, D. Russell, R. Duman. Journal of Neuroscience, 2002

1,647 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/3a8edbde1ad77b2aedc833527c5cfe4dc8f73a73

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus (2005, background): “Infusion of BDNF into the hippocampus and midbrain area produces antidepressant-like behavioral effects in rats (Siuciak et al., 1997; Shirayama et al., 2002), and transgenic mice with reduced BDNF signaling in the brain are insensitive to antideReceived Sept. 9, 2004; revised Dec. 10, 2004;…”
Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment (2003, background): “It has been demonstrated in our laboratory (Shirayama et al, 2002) that 25–30% of normal animals exposed to IS do not show the predicted escape deficit.”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, methodology): “…the FST and LH models are observed after infusion of BDNF into the dentate gyrus granule cell layer or the CA3 pyramidal cell layer, but not the CA1 pyramidal cell layer, which indicates that these behavioral effects are specific to distinct subregions of the hippocampus (Shirayama et al., 2002).”
New approaches to antidepressant drug discovery: beyond monoamines (2006, background): “Direct evidence for this hypothesis comes from experiments in which injection of BDNF into the rodent hippocampus exerts antidepressant-like effects in the forced swim and learned helplessness test”
Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects (2003, background): “Because a recent study showed that intrahippocampal infusion of neurotrophin-3 produced antidepressant-like behavioral effects (Shirayama et al., 2002), we also investigated the effect of imipramine on cortical neurotrophin-3 protein levels.”
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “Moreover, infusion of BDNF into the midbrain, ventricles, or regions of the hippocampus results in increased antidepressant-like behavior (Shirayama et al., 2002; Hoshaw et al., 2005; Hu and Russek, 2008).”
BDNF — a key transducer of antidepressant effects (2015, background): “As previously discussed, bilateral BDNF-infusions into the hippocampus or the ventricles induces antidepressant-like effects in preclinical animal models that can persist for several days (Shirayama et al., 2002; Siuciak et al., 1997).”
Discovering Endophenotypes for Major Depression (2004, background): “Thus, it was observed that CREB overexpression in the dentate gyrus or BDNF injection results in an antidepressant-like effect in the learned–helplessness paradigm and the forced swim test model of antidepressant efficacy in rats (Chen et al, 2001; Shirayama et al, 2002).”
BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. (2005, background): “, 2002), a nearly identical bilateral infusion of BDNF has antidepressant-like effects in behaving rats (Shirayama et al., 2002).”
Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, positive): “This practice, stemming from the “neurotrophic hypothesis” of depression (65), is based on three main observations: an impairment of hippocampal BDNF signaling produces certain depression-related behaviors and impairs the actions of antidepressants (66-68), experimental increases in hippocampal BDNF”