Antigen-presenting cell function in the tolerogenic liver environment

By A. Thomson, P. Knolle. Nature reviews. Immunology, 2010

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Gut Microbiota and Immune System Interactions (2020, neutral): “immune-mediated pathologic conditions [45].”
Kupffer Cells in the Liver (2013, neutral): “In a healthy liver, the Kupffer cell exhibits what has been termed a “tolerogenic” phenotype. present on dead or dying cells as they are cleared from the circulation in the liver (139).”
Microbiota in health and diseases (2022, background): “The gut microbiota has been closely connected to immunological response due to the fact that enteric microorganisms may promote macromolecules and antigens through the gut epithelium.(102) The principal component of bacterial flagellum, namely flagellin, elaborates the relationship between gut epith”
Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance. (2014, background): “This function of the liver is offset by the local immune tolerance to non-pathogenic exogenous material [5].”
Emerging Issues in AAV-Mediated In Vivo Gene Therapy (2017, background): “It has been shown that AAV vector-mediated expression of human FIX in hepatocytes leads to tolerance to the transgene product,(51) a phenomenon that is not entirely surprising, given the unique immunological environment of the liver, which is placed at the crossroads between the gut and the bloodstr”