MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.

By M. Carmell, Angélique Girard, H. V. D. van de Kant, D. Bourc’his, T. Bestor, D. D. de Rooij, Gregory J. Hannon. Developmental Cell, 2007

1,159 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/e50d5b70f7d7215cb63d7f3e4f14be00ef58f265

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Citations in the corpus

Epigenetic reprogramming and small RNA silencing of transposable elements in pollen (2009, neutral): “In rodents, piRNAs produced in the male germline silence TEs and directly or indirectly target these regions for DNA methylation (Carmell et al., 2007), a silencing signal that is potentially heritable through subsequent cell divisions after piRNAs are no longer present.”
3’ end processing of a long nuclear-retained non-coding RNA yields a tRNA-like cytoplasmic RNA (2008, neutral): “, 2007) and piRNAs that silence transposons in the germline (Brennecke et al., 2007; Carmell et al., 2007), additional classes of small RNAs have been recently discovered.”
Small non-coding RNAs in animal development (2008, background): “Meiotic defects were observed in Miwi2 mutants, along with the disappearance of spermatogonia in adult animals, resulting in completely empty seminiferous tubules”
Establishing, maintaining and modifying DNA methylation patterns in plants and animals (2010, background): “In mammals, decreases in DNA methylation and increases in expression were observed at several TEs in two Piwi clade mutants, Mili (also known as Piwil2 ) and Miwi2 (also known as Piwil4”
Child health, developmental plasticity, and epigenetic programming. (2011, background): “particle (IAP) transposable elements in the testis (112).”
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. (2008, positive): “Mutations in Piwi family genes have been shown to increase retrotransposon transcription in Drosophila (Sarot et al. 2004; Kalmykova et al. 2005), Trypanosoma (Shi et al. 2004), Neurospora (Nolan et al. 2005), and mice (Aravin et al. 2007; Carmell et al. 2007).”