Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.

By J. Brennecke, Alexei Aravin, Alexander Stark, Monica Dus, Manolis Kellis, Ravi Sachidanandam, Gregory J. Hannon. Cell, 2007

2,512 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/31d83aeea53ced8f5ba668b2ff4fde33debc941f

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Citations in the corpus

Revisiting the principles of microRNA target recognition and mode of action (2009, background): “The 5′ ends of a separate class of small RNAs in animals, the Piwi-interacting RNAs (piRNAs), are also formed by slicin”
Argonaute proteins: key players in RNA silencing (2008, background): “In addition, the cleavage activity of Piwi-like proteins is probably required for the maturation of repeat-associated small interfering (rasi)RNAs and Piwi-interacting RNAs (piRNAs) in flies and mammal”
Targeting the dynamic HSP90 complex in cancer (2010, background): “Transposons are suppressed by an RNA-silencing mechanism that is mediated by Piwi-interacting RNAs (piRNAs)”
Next-generation DNA sequencing methods. (2008, background): “Perhaps the most profound impact of next-generation sequencing technology has been on the discovery of novel ncRNAs belonging to distinct classes in an extraordinarily diverse set of species (3, 8, 9, 18, 22, 29, 41, 55).”
Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation (2012, neutral): “They lack the 3’-end modification and they originate from fragmentation of longer transcripts in a Dicer-independent manner (Brennecke et al., 2007; Vagin et al., 2006; Thomson and Lin, 2009).”
ShortStack: comprehensive annotation and quantification of small RNA genes. (2013, methodology): “In Drosophila , most mature miRNAs are between 21 and 23 nt in length, piRNAs are mostly 26 – 28 nt in length, and endo-siRNAs are tightly centered on 21 nt in length (Brennecke et al. 2007; Czech et al. 2008; Okamura et al. 2008; Berezikov et al. 2011).”
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. (2007, background): “These bodies have been implicated in RNAi- and miRNA-mediated silencing but have also been shown to be able to release mRNAs into the actively translating pool of mRNAs ( Brengues et al., 2005 ), suggesting that they may act as mRNA-storage particles.Inmice,MIWIhasbeenlocalized to the chromatoid bod”