Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse.

By S. Luther, H. L. Tang, P. Hyman, A. Farr, J. Cyster. Proceedings of the National Academy of Sciences of the United States of America, 2000

687 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/2ac1c5499197a5f75645c576a7c241433d658bf9

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In Immunology

1. J. Cyster
2. A. Luster
3. J. Girard
4. Christopher D. C. Allen
5. T. Okada
6. R. Förster
7. R. Lesley
8. K. Ansel

In Oncology

1. J. Cyster
2. A. Luster
3. G. Randolph
4. V. Angeli
5. Christopher D. C. Allen
6. R. Mebius
7. B. Hinz
8. M. Krummel

Citations in the corpus

• Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1 (2007, methodology): “To determine whether the CXCR5-expressing T cells were being retained at the follicular boundary by T zone chemokines, transgenic or control cells were transferred into CCR7 ligand-deficient plt/plt recipients (35, 36).”
• Dendritic-cell trafficking to lymph nodes through lymphatic vessels (2005, background): “In a naturally occurring mouse mutant, the plt mouse, some of the genes that encode CCL19 and the CCL21 variants are absent, as part of a chromosomal abnormalit”
• International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “CXCL13 is also required for B1 cell homing, natural antibody production, body cavity immunity, and lymphoneogenesis in the setting of autoimmunity (Luther et al., 2000; Ansel et al., 2002).”
• Structure and function of the spleen (2005, background): “There is a similar mechanism for regulating the integrity of the T-cell zone, in which the chemokines CCL19 and CCL21 (which are mainly produced by stromal cells in the T-cell zone) are crucial for the attraction and retention of T cell”
• Differing Activities of Homeostatic Chemokines CCL19, CCL21, and CXCL12 in Lymphocyte and Dendritic Cell Recruitment and Lymphoid Neogenesis1 (2002, methodology): “Debris was removed by centrifugation and supernatant was either used as whole lysate or immunoprecipitated using heparinSepharose as previously described (16).”
• CCR7 and its ligands: balancing immunity and tolerance (2008, background): “In Paucity of lymph-node T cells ( plt/plt ) mice — a naturally occurring strain of mutant mice that carry an autosomal recessive mutation — a large gene locus that contains the genes encoding CCL19 and CCL21-Ser has been deleted, leaving the gene that encodes CCL21-Leu intac”
• Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position (2002, background): “To test this in vivo , we transferred Ig HEL -transgenic B cells to plt/plt mice that lack the CCL19 gen”
• Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells (2007, background): “These cells also produced the CCR7 ligands, CCL19 and CCL21, required for T cell recirculation, as suggested befor”
• Orchestrating the orchestrators: chemokines in control of T cell traffic (2008, background): “CCL19 and CCL21 are encoded by two closely linked gene clusters and are expressed differently by different lymph node cell”
• Lymphoid organ development: from ontogeny to neogenesis (2006, background): “CCL19 (also called ELC) and CCL21 (also called SLC) are constitutively expressed by T cell–zone stromal cells and share the chemokine receptor CCR7, which orchestrates the homing of naive and central memory T cells and DCs to the T cell compartmen”