Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1

By N. Haynes, Christopher D. C. Allen, R. Lesley, K. Ansel, N. Killeen, J. Cyster. Journal of Immunology, 2007

722 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cd73ee8e5607f075a4d4874f64ac1772ccc1ea38

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In Immunology

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T follicular helper cell differentiation, function, and roles in disease (2014, background): “B cells serve both as antigen-presenting cells (APCs) and as a source of ICOSL (Choi et al., 2011; Haynes et al., 2007; Nurieva et al., 2008).”
Generation of follicular helper T cells is mediated by IL-21 but independent of TH1, TH2 or TH17 lineages (2008, background): “, 2004) and a recent report indicating that Tfh cells express programmed death-1 (PD-1) protein (Haynes et al., 2007), PD-1 mRNA was highly upregulated in Tfh cells compared to other Th cell subsets (data not shown).”
The Chemokine Superfamily Revisited (2012, positive): “Downregulation of CCR7 is also necessary for B and follicular helper T cells expressing CXCR5 to redirect their migration to the B cell zone via CXCL13 expressed by follicular dendritic cells (Haynes et al., 2007).”
FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “Another CD28 family member, PD-1, that has been implicated in the negative regulation of chronically activated T cells has also been demonstrated on GC Tfh cells in human tonsil and mouse (Haynes et al., 2007).”
Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses (2013, positive): “A coordinated increase in CXCR5 and decrease in CCR7 is important for CD4+ T cell localization to B cell follicles (Haynes et al., 2007), and lower levels of CCR7 might allow for a deeper migration into B cell follicles in vivo.”
Bcl6 dependent T follicular helper cell differentiation diverges from effector cell differentiation during priming and depends on the gene Icos (2011, positive): “Tfh cells physically within germinal centers (GC Tfh cells) have the highest PD-1 expression (Haynes et al., 2007) and can be distinguished on the basis of GL7 expression in mice with an acute viral infection (Yusuf et al., 2010).”
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. (2009, background): “Upregulation of CXCR5 and downregulation of CCR7 on Tfh cells determine their follicular positioning and thus are important for their function (Hardtke et al., 2005; Haynes et al., 2007).”
Germinal-center organization and cellular dynamics. (2007, background): “T cells constitute approximately 5%–20% of GC cells and are enriched within the light zone, though low numbers can also be found in the dark zone (Arnold et al., 2007; Brachtel et al., 1996; Haynes et al., 2007).”