CCR7 and its ligands: balancing immunity and tolerance

By R. Förster, A. Davalos-Misslitz, A. Rot. Nature reviews. Immunology, 2008

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View Paper: https://www.semanticscholar.org/paper/6fcb76b7adafd0698f3d3a1e224c7a832f30d94b

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Citations in the corpus

Lymphangiogenesis: Molecular mechanisms and future promise. (2010, background): “The LECs in afferent lymphatic vessels attract activated dendritic, T, and B cells expressing the chemokine receptor CCR7 by producing its ligand CCL21 (also known as secondary lymphoid chemokine, SLC) (Forster et al., 2008).”
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing. (2017, neutral): “Naive T cells with CCR7 expression and effector memory T cells withCX3CR1were prevalent in peripheral blood, while MAIT cells were prevalent in nontumor adjacent liver tissue.”
The lymphatic vasculature in disease (2011, background): “The LECs of afferent lymphatic vessels attract activated DCs, T cells and B cells expressing the chemokine receptors CCR7 and CCR10 by secreting their ligands CCL21 (also known as secondary lymphoid chemokine) and CCL27 (precollector vessels), respectivel”
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “…the defect in negative selection of thymocytes and in lymph node homing and function of regulatory T cells, immune responses may even take an exaggerated course in Ccr72/2 mice, leading to development of spontaneous autoimmunity (Kurobe et al., 2006; Schneider et al., 2007; Forster et al., 2008).”
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “Upon LPS injection in the periphery, BM CDPs downregulate CXCR4, allowing them to leave the BM, up-regulate CCR7, and home to the LNs, where they differentiate into DCs (249).”
Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy (2019, background): “Two cell clusters (#19, 29) expressed high levels of the naive/CM signature, including the chemokine receptor CCR7 and the selectin CD62L (SELL), known to promote the recruitment of naive and central memory (CM) T cells to the T cell areas of secondary lymphoid organs through the high endothelial ve”