Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila.

By J. Yin, J. S. Wallach, M. D. Vecchio, E. Wilder, H. Zhou, W. G. Quinn, Tim Tully. 1994

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Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “The molecular and cellular mechanisms underlying aversive LTM are known to differ from those responsible for memories with shorter retention times (Yin et al., 1994; Pascual and Preat, 2001; Dubnau et al., 2003; Comas et al., 2004; Isabel et al., 2004; Yu et al., 2006; Blum et al., 2009; Akalal et a”
Plasticity in the human central nervous system. (2006, background): “The importance of CREB was initially demonstrated in invertebrates (Dash et al., 1990; Yin et al., 1994, 1995).”
Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila (2008, methodology): “CXM feeding and manipulation of rsh, cerP, teqf01792, and hs-dCreb2-b (with and without heat shock) has previously been determined to have no adverse effect on odor acuity (Folkers et al., 1993; Yin et al., 1994; Comas et al., 2004; Didelot et al., 2006).”
The Biology of Forgetting – A Perspective (2017, background): “…a molecular cascade initiated by changes in gene expression at acquisition within engram cells through cAMP-dependent mechanisms that include Creb, C/EBP, and other transcription factor families (Yin et al., 1994; Bailey et al., 1996; Dudai, 2004; Kandel et al., 2014; Alberini and Kandel, 2014).”
The Emotional Brain, Fear, and the Amygdala (2003, background): “Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory.”
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB (2012, background): “Finally, although we have focused on CREB- dependent gene expression is present in flies given its conserved role in memory formation through evolution, other transcription factors, such as SRF, c-fos, EGR-1 or NF-κB [64-67] are also likely to contribute to the transcriptional regulation that accomp”
Drosophila α/β Mushroom Body Neurons Form a Branch-Specific, Long-Term Cellular Memory Trace after Spaced Olfactory Conditioning (2006, unknown): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript that 12-14 hr CXM-feeding prior to associative conditioning is sufficient to reduce 24-hr memory following spaced training (Yin et al., 1994).”
Olfactory memory formation in Drosophila: from molecular to systems neuroscience. (2005, background): “…containing a blocking isoform of CREB, dCREB2-b, expressed from a heat-shock promoter, have been generated and used to block dCREB2-activating isoforms in otherwise wild-type flies prior to spaced training experiments, and this produced a specific impairment in long-term memory (Yin et al. 1994).”
The molecular and systems biology of memory. (2014, unknown): “Other transcription factors also contribute to the regulation of transcription that accompanies long-lasting synaptic change in different forms of learning and in different animal species (Albensi and Mattson, 2000; Izquierdo and Cammarota, 2004; Yin et al., 1994; Waddell and Quinn, 2001).”
Transcription Factors in Long-Term Memory and Synaptic Plasticity (2009, unknown): “Genetic mutations of the CREB gene pointed to the existence of both activator and inhibitor isoforms of CREB (262).”
Transcriptional regulation by the phosphorylation-dependent factor CREB (2001, background): “Overexpression of a dominant-negative CREB isoform in the fruitfly Drosophila melanogaster blocks memory consolidation in an olfactory learning model, whereas expression of a dominant-active CREB polypeptide accelerates the learning proces”
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila (2019, unknown): “As previously reported, feeding the flies with cycloheximide (CXM) 12-16 h before spaced training (Tully et al., 1994; Yin et al., 1994) impaired LTM performance when flies were tested for their preference between All rights reserved.”