The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

By E. Kandel. Molecular Brain, 2012

849 citations recorded by the source corpus.

The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world. These are six key steps in the molecular biological delineation of short-term memory and its conversion to long-term memory for both implicit (procedural) and explicit (declarative) memory. I here first trace the background for the clinical and behavioral studies of implicit memory that made a molecular biology of memory storage possible, and then detail the discovery and early history of these six molecular steps and their roles in explicit memory.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/10ff5f796feb742436ec46cc116058f4b8b2c74f

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In Cellular and Molecular Neuroscience

Citations in the corpus

Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation (2013, background): “Recent advances in several animal models have suggested two distinct components of synaptic capture that stabilize long-term functional and structural changes at specific synapse: one requires CREB-regulated transcription and NMDA receptor/PKA activities, whereas the other requires CPEB-regulated tr”