Transcriptional regulation by the phosphorylation-dependent factor CREB

By Bernhard M. Mayr, M. Montminy. Nature reviews. Molecular cell biology, 2001

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The Role of the Transcription Factor CREB in Immune Function (2010, background): “Furthermore, CREB has been shown to induce transcription of immune-related genes that possess a CRE element, including IL-2, IL-6, IL-10, TNF-a, cyclooxygenase-2, and macrophage migration-inhibitory factor (2, 9, 10).”
PONDR-FIT: A Meta-Predictor of Intrinsically Disordered Amino Acids (2010, background): “The key steps involved in CREB-mediated gene transcription include dimerization, binding at the cAMP response element (CRE), a specialized stretch of DNA that contains the consensus nucleotide sequence TGACGTCA, and phosphorylation of a single serine residue by calmodulin-dependent kinases [72–73].”
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “CREB is well known as a target of mitogenic signaling pathways (137).”
Regulation of gene expression and cocaine reward by CREB and ΔFosB (2003, background): “CREB is ubiquitously expressed and is activated through the cAMP pathway as well as several other second-messenger system”