Bacterial CpG‐DNA and lipopolysaccharides activate Toll‐like receptors at distinct cellular compartments
By P. Ahmad-Nejad, Hans Häcker, Mark Rutz, S. Bauer, R. Vabulas, H. Wagner. European Journal of Immunology, 2002
818 citations recorded by the source corpus.
Subfields: Immunology, Public Health, Environmental and Occupational Health, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/2a44bbef3b02077ddbdc031df4951cee2bf5fcd6
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Citations in the corpus
- Toll-like receptor signalling (2004, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54106">TLR9 , all of which are involved in the recognition of nucleic-acid-like structures, are not expressed on the cell surfac”
- Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock (2007, methodology): “After blocking of unspecific binding sites with fetal calf serum (10%, 4 °C, overnight) samples were processed for single-labeling immunofluorescence using a polyclonal rabbit antibody to human MyD88 (Alexis Biochemicals”
- Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells (2005, background): “Although most TLRs are present on the cell surface, TLR7, TLR8 and TLR9 are in the endosomal compartmen”
- Therapeutic potential of Toll-like receptor 9 activation (2006, background): “The earliest steps in the CpG-induced signal transduction pathways can be blocked by inhibitors of endosomal acidification/maturatio”
- Toll-like receptors. (2003, background): “Recently, a monoclonal antibody against TLR9 has been established, and staining with this antibody indicated the intracellular localization of endogenous TLR9 in a mouse macrophage cell line (134).”
- Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines (2011, neutral): “somal trafficking or acidification, respectively (7, 9).”
- Pathogen recognition and innate immunity. (2006, neutral): “single-stranded CpG-motif-containing regions that subsequently interact directly with TLR9 (Ahmad-Nejad et al., 2002; Latz et al., 2004).”
- Innate immune sensing and its roots: the story of endotoxin (2003, background): “Some seem to reside in cells, others at the surfac”
- Immune sensing of DNA (2013, neutral): “It is now well established that unmethylated CpG DNA motifs, which are abundant in many pathogen genomes, have the ability to stimulate immune responses through an endosomal TLR pathway, whereas classical B form double-stranded (ds) DNA is a potent immune stimulator when present in the cytosol (Figu”