Therapeutic potential of Toll-like receptor 9 activation

By A. Krieg. Nature reviews. Drug discovery, 2006

1,288 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/3e517db13668b0eb790ef83c8f11d6dd1ed97778

How researchers see this paper

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In Immunology

1. A. Mantovani
2. P. Allavena
3. B. Guy
4. R. Ransohoff
5. G. Solinas
6. G. Germano
7. A. Sher
8. Zhi-ren Zhang

Citations in the corpus

• Cooperation of Toll-like receptor signals in innate immune defence (2007, background): “These agonists seem to be particularly effective when they are covalently conjugated to the immunogen”
• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “Several studies have shown that the activation of TLRs (for instance, TLR9) stimulates M1-polarized macrophage responses by inducing the activation of a proinflammatory program [133].”
• The perfect mix: recent progress in adjuvant research (2007, background): “For instance, TLR agonists can stimulate T cells directly or indirectl”
• Aptamers and Their Biological Applications (2012, background): “In addition, many aptamer-based drugs, such as AS1411 (a nuclein-specific aptamer) for acute myeloid leukemia, ARC1779 (a vonWillebrand factor-specific aptamer) for carotid artery disease, and NU172 (a thrombin-specific aptamer) for anticoagulation, are currently in a clinical trials [80–86].”
• Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “Moreover, unmethylated CpG has been reported of immunostimulatory effect in mice and other mammals, as well as in-vitro human cell lines [20, 21].”
• Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “Several articles have reported that activation of TLRs stimulates M1-polarized macrophage response, which induce the activation of proinflammatory program [116].”
• Interferons at age 50: past, current and future impact on biomedicine (2007, background): “Development of chemical modulators that selectively activate IFN synthesis or block the synthesis of inflammatory cytokines could have a broad therapeutic potentia”
• Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns (2010, background): “In mice, TLR9 is expressed by all DC subsets, but in humans its expression is restricted to pDC”
• Aptamers as therapeutics (2010, background): “Innate immune responses mediated by TLR9 include the activation of antigen-specific B cells and the secretion of cytokines including interleukin-6 and interferon 63,64 .”