Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

By A. Kužnik, M. Benčina, U. Švajger, M. Jeras, B. Rozman, R. Jerala. Journal of Immunology, 2011

619 citations recorded by the source corpus.

Subfields: Immunology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/a3d506dd63d0332497ddda161bc43ba561f36473

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In Immunology

1. Giselle Chamberlain
2. R. Thwaites
3. S. Sacre

Citations in the corpus

• Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis (2013, background): “The mechanism was suggested to be due to the inhibition of endosomal acidification; however, more recently antimalarials have been shown to interact directly with nucleic acids, causing modifications which prevent their binding to the endosomal TLRs (73).”
• Lysosomes as a therapeutic target (2019, background): “Toxicity of CQ/HCQ, in particular in the eye (cornea and macula) and the occurrence of cardio myopathies 212 , remains a major limitation.”