Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?

By M. A. Curotto de Lafaille, J. Lafaille. Immunity, 2009

1,159 citations recorded by the source corpus.

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In Immunology

Citations in the corpus

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells (2012, background): “The mucosal immune system is considered a primary site for iT reg cell generation (Curotto de Lafaille and Lafaille, 2009).”
Expanding roles for CD4+ T cells in immunity to viruses (2012, background): “An important factor in the generation of induced T Reg cells appears to be TGF”
A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “It has been supposed that nTreg mainly protects against autoimmunity in situ, but iTreg primarily inhibits immune responses against environmental and food antigens in the gut [178].”
Control of regulatory T cell lineage commitment and maintenance (2009, background): “In addition, peripheral naive CD4 T cells are also capable of Foxp3 upregulation during differentiation into so-called induced Treg cells or iTreg cells (Figure 1; reviewed in this issue of Immunity by Curotto de Lafaille and Lafaille [2009]).”
Plasticity of CD4+ T cell lineage differentiation. (2009, background): “Two major categories of Foxp3+ Treg cells have been identified: the naturally occurring CD4+ CD25+ Treg (nTreg) cells that arise in the thymus and the TGF-b-induced iTreg cells produced in the periphery (Curotto de Lafaille and Lafaille, 2009; Josefowicz and Rudensky, 2009, both in this issue).”
The polarization of immune cells in the tumour environment by TGFβ (2010, background): “T Reg cells are an immunosuppressive T cell population that express the transcription factor FOXP3 and can suppress antitumour immune response”
T Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis (2012, background): “derived in the periphery from na€ ve CD4þ T-cell precursors under tolerogenic conditions (2).”
Intestinal bacterial colonization induces mutualistic regulatory T cell responses. (2011, background): “…show here that colonization of germ-free mice with clearly defined and absolutely benign intestinal commensal altered Schaedler flora (ASF) species (Dewhirst et al., 1999) resulted in the compartmentalized expansion, activation, and de novo generation of mucosal Treg cells specifically in the…”