Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus

By M. Saxe, F. Battaglia, Jing-wen Wang, G. Malleret, D. David, J. Monckton, A. Garcia, M. Sofroniew, E. Kandel, L. Santarelli and 2 more. 2006

1,075 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “These studies have revealed that neurogenesis is required for some but not other hippocampus-dependent tasks, and is not required for tasks that do not involve the hippocampu”
Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies (2009, background): “newly generated neurons [2,24].”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “…of studies have shown that adult hippocampal neurogenesis is required for different hippocampaldependent behavioral responses including the effects of chronic antidepressant treatments (Santarelli et al., 2003) and memory function (Snyder et al., 2005; Saxe et al., 2006; Winocur et al., 2006).”
Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats (2010, neutral): “These young, adult-born granule cells contribute significantly to behavioural functions such as contextual fear memory, spatial pattern separation and spatial learning (Clelland et al. 2009; Kitamura et al. 2009; Saxe et al. 2006).”
Neurogenesis in the Adult Hippocampus. (2015, background): “, inhibited) conditions originates from the newborn neurons, which are not yet inhibited by the local interneurons (Saxe et al. 2006; Garthe et al. 2009).”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, background): “Ablation of neurogenesis impairs some aspects of learning and memory (Imayoshi et al., 2008; Saxe et al., 2006; Snyder et al., 2005b).”
Adult neurogenesis and the olfactory system. (2009, background): “Ablating neurogenesis impairs spatial memory and contextual fear conditioning (Saxe et al., 2006; Imayoshi et al., 2008), but actually improved performance on some working memory tasks (Saxe et al., 2007).”
Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior (2008, methodology): “BDNF LTP neurogenesis plasticity dendritogenesis The life-long generation of new neurons is well documented inthe subgranule zone of the dentate gyrus in the hippocampus (1–4).”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “Saxe et al (2006) found that ablation of new neurons impaired dentate gyrus LTP (as measured in vitro) and Neuroplasticity and depression C Pittenger and RS Duman…”
How widespread is adult neurogenesis in mammals? (2007, background): “Several studies have linked adult-generated neurons in the rodent hippocampus to learning and memor”
Adult-born hippocampal neurons are more numerous, faster-maturing and more involved in behavior in rats than in mice (2009, methodology): “Our results seemingly contradict other findings showing contributions of adult neurogenesis to fear conditioning in mice (Saxe et al., 2006; Imayoshi et al., 2008).”
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain (2009, background): “, 2008), but disagrees with other studies (Saxe et al., 2006; Winocur et al., 2006).”
Synapse formation on neurons born in the adult hippocampus (2007, background): “, new neurons are functional and may be important in hippocampus-dependent learnin”
The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory (2008, background): “toxin, x-ray irradiation, or virus-activated pro-drugs results in profound cognitive deficits [24–28].”
Adult neurogenesis and the plasticity of the dentate gyrus network (2011, background): “…neurogenesis using pharmacology, irradiation or transgenesis impairs specific forms of hippocampus-dependent learning and behavior in rodents (Shors et al., 2001; Santarelli et al., 2003; Abrous et al., 2005; Saxe et al., 2006; Winocur et al., 2006; Dupret et al., 2008; Clelland et al., 2009).”
Adult hippocampal neurogenesis in depression (2007, background): “Blocking hippocampal neurogenesis does not influence anxiety-related behavior as assessed in conflict-based tests, such as the open field, light-dark choice test, and elevated plus-maz”
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus (2010, methodology): “These have shown that neurogenesis may support hippocampal-dependent behaviors such as contextual fear conditioning (Deng et al., 2009; Saxe et al., 2006), specific Morris water maze paradigms (Deng et al.”