Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

By M. Bergami, R. Rimondini, S. Santi, R. Blum, M. Götz, M. Canossa. 2008

411 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

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Citations in the corpus

Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement (2014, background): “Bergami et al., 2008; Waterhouse et al., 2012 GABA Neurotransmitter DG Ge et al., 2006 Glutamate Neurotransmitter SVZ Platel et al., 2010 WNT Morphogen DG Lie et al., 2005; Kuwabara et al., 2009 INTRACELLULAR FACTORS NFATc4 Transcription factor DG Quadrato et al., 2012 NF-KappaB p50 Transcription…”
RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus (2010, background): “, 2003), anxiety and depression (Bergami et al., 2008; Revest et al., 2009), and epilepsy (Jessberger et al.”
Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus (2012, background): “Indeed survival of newborn neurons is dependent upon their input synaptic activity (10); interestingly, newborn neurons lacking the full-length TrkB receptor show impaired synaptic plasticity and therefore an increased death rate at the transition from the immature to the mature stage (8).”
Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity (2010, background): “synaptic plasticity [78] and neurogenesis [79] in the hippocampus.”
The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity (2010, background): “…the hippocampal dentate gyrus (Madsen et al., 2000; Malberg et al., 2000; Warner-Schmidt and Duman, 2006) and in some cases, neurogenesis appears to be important for the behavioral effects of antidepressant drugs (Santarelli et al., 2003; Bergami et al., 2008; Li et al., 2008; David et al., 2009).”
Brain-derived Neurotrophic Factor Promotes Differentiation and Maturation of Adult-born Neurons Through GABAergic Transmission (2012, result): “In agreement with this view, considerable evidence links BDNF and adult neurogenesis (Lee et al., 2002b; Sairanen et al., 2005; Scharfman et al., 2005; Bergami et al., 2008; Chan et al., 2008; Li et al., 2008); however, these studies have reported conflicting results.”
Krüppel-Like Factor 9 Is Necessary for Late-Phase Neuronal Maturation in the Developing Dentate Gyrus and during Adult Hippocampal Neurogenesis (2009, background): “Since Klf-9 loss of function primarily affects the “mature” Dcx population and results in decreased survival of 4- to 6-week-old adult-born neurons, we investigated whether the functional integration of adult-born neurons was impaired in Klf-9-null mice by analyzing ACSF-LTP.”
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity (2017, background): “An accumulating body of evidence indicates action of BDNF during the later stages of neurogenesis (Bergami et al. 2008; Chan et al. 2008; Wang et al. 2015).”
Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases (2013, background): “Conditional deletion of TrkB in adult NSPCs leads to a specific reduction in dendritic arborization and spine density (Bergami et al., 2008).”