Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

By Dongmei Ren, N. Villeneuve, T. Jiang, Tongde Wu, Alexandria Lau, Henry A Toppin, Donna D. Zhang. Proceedings of the National Academy of Sciences of the United States of America, 2011

636 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/2237ed467485632de41be62abaa76d6a6aa643ac

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Citations in the corpus

Nrf2, the Master Regulator of Anti-Oxidative Responses (2017, background): “The quassinoid, brusatol, was identified in an ARE-luciferase screen and was shown to transiently deplete Nrf2 in a concentration-dependent manner [119,120].”
Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes (2012, background): “Ren et al. (2011) reported that brusatol, an inhibitor of the Nrf2 pathway, sensitized a broad spectrum of cancer cells and A549 xenografts to cisplatin and other chemotherapeutic drugs by inhibiting the Nrf2-mediated defense mechanism.”
Role of Glutathione in Cancer Progression and Chemoresistance (2013, background): “On the other hand, the inhibition of Nrf2 signalingmight be employed to enhance the sensitization of chemoresistant tumors to cytotoxic agents, and in this context, it has recently been reported that brusatol, a compound found in a plant extract, acts as inhibitor of this pathway and may exhibit the”
The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. (2017, neutral): “However, the NRF2 inhibitor brusatol (Ren et al., 2011) and the alkaloid trigonelline (Arlt et al.”
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer (2013, background): “a r t i c l e i n f o”
Glutathione metabolism in cancer progression and treatment resistance (2018, background): “The plant-derived compound brusatol also decreases NRF2 protein levels (Ren et al., 2011), and use of any of these compounds improves sensitivity to chemotherapeutics such as cisplatin and gemcitabine.”
p62 links autophagy and Nrf2 signaling. (2015, background): “More importantly, adjuvant therapy using the Nrf2 inhibitor brusatol imparted drug sensitivity to chemoresistant cancer cells, and enhanced the survival of mice bearing KRas-induced lung tumors [59,60].”
The emerging role of the Nrf2–Keap1 signaling pathway in cancer (2013, background): “Recently, our laboratory screened many plant extracts to identify Nrf2 inhibitors and found that brusatol, a component of Brucea javanica seeds, is able to inhibit the Nrf2 pathway (Ren et al. 2011).”
Metallothionein-1G Facilitates Sorafenib Resistance through Inhibition of Ferroptosis (2016, neutral): “, ATRA,((21)) trigonelline,((22)) and brusatol((23))) limited sorafenib-induced NRF2 transcriptional activity (Fig.”