AP-1 as a regulator of cell life and death

By E. Shaulian, M. Karin. Nature Cell Biology, 2002

2,963 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/26ecaf32410b1d9cdbdee98801adbcaf201c94e1

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Citations in the corpus

Understanding MAPK Signaling Pathways in Apoptosis (2020, background): “AP-1 regulates a wide range of cellular processes, including cell proliferation, differentiation, cell survival, and apoptosis [20,21].”
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal (2014, background): “AP-1 transcription factors control cell proliferation, survival, and death.”
Overview of Nomenclature of Nuclear Receptors (2006, background): “…to ligands, some NRs regulate gene programs not only by directly binding to HREs but also through signal transduction cross-talk, for example by interfering with AP-1 and NF-(cid:2) B activities that are the prototypes of a negative regulation (Gottlicher et al., 1998; Shaulian and Karin, 2002).”
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. (2011, background): “This phosphorylation, which is mediated by all three JNK isoforms and to some extent by other MAPKs, induces the full transcriptional activity within the AP-1 complex, independent of DNA binding [156].”
The circadian clock: pacemaker and tumour suppressor (2003, background): “ERK signalling leads to the activation of AP1 transcription factors, which are dimeric basic leucine zipper proteins from the Jun and Fos familie”
The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease (2007, background): “Given the central role of NF-κB and AP1 in immune response”
Nuclear retinoid receptors and the transcription of retinoid-target genes. (2004, background): “The best example is that of the AP-1-regulated genes (Shaulian and Karin, 2002).”
Inflammatory bone loss: pathogenesis and therapeutic intervention (2012, background): “AP1 regulates the differentiation and proliferation, as well as apoptosis, of various cell type”
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. (2003, background): “Correspondingly, various target genes of AP-1 and NF- B were identified as proliferative and apoptotic cellular responses (8, 14, 15, 28, 30).”
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation (2008, background): “Many mitogens induce JUN activity, and JUN functions as part of the AP1 transcription factor to exert its positive effect on cell proliferatio”