FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

By M. Welcker, B. Clurman. Nature Reviews. Cancer, 2008

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Reflecting on 25 years with MYC (2008, background): “Levels of regulation additional to this core model have recently been proposed, suggesting several potential approaches for neoplastic interventio”
Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis (2017, background): “evidence has shown that they are functionally identical as the C-terminal F-Box and WD-40 domains are common among them (41,42).”
Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics (2012, neutral): “Many of these novel RDPs contain known degradation targeting motifs, such as Anaphase Promoting Complex (APC/C) KEN-boxes (32, 33), APC/C D-boxes (33, 34), and Skp1-Cullin-Fbox (SCF) FBXW7-binding sites (35, 36) (supplemental Table S3).”
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer (2008, background): “Such is the case for FBXW7 , which has a central role in cell cycle progression, cellular growth and differentiation by targeting oncogenic proteins for degradation, and several cancer-associated mutations have been shown to exist in FBXW7 (Ref”