Understanding MAPK Signaling Pathways in Apoptosis

By Jicheng Yue, José M. López. International Journal of Molecular Sciences, 2020

1,062 citations recorded by the source corpus.

MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus. In this review, we present the main pro- and anti-apoptotic mechanisms regulated by MAPKs, as well as the crosstalk observed between some MAPKs. We also describe the basic signaling properties of MAPKs (ultrasensitivity, hysteresis, digital response), and the presence of different positive feedback loops in apoptosis. We provide a simple guide to predict MAPKs’ behavior, based on the intensity and duration of the stimulus. Finally, we consider the role of MAPKs in osmostress-induced apoptosis by using Xenopus oocytes as a cell model. As we will see, apoptosis is plagued with multiple positive feedback loops. We hope this review will help to understand how MAPK signaling pathways engage irreversible cellular decisions.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0ec8eda064d63bdd78cee4f60dcac40c53ab451a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

  1. Cheng Peng
  2. Bo Han
  3. Minru Liao
  4. Shiou Zhu
  5. Fu Peng
  6. Rui Qin
  7. Yi Chen
  8. L. Fu

Citations in the corpus