Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development

By S. Kosak, J. Skok, K. Medina, R. Riblet, M. L. Le Beau, A. Fisher, Harinder Singh. Science, 2002

781 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/26ce3d4cfeb532c2e87dbd69d87dbe61146aeaba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

Citations in the corpus

Recruitment to the Nuclear Periphery Can Alter Expression of Genes in Human Cells (2008, background): “The data that we have presented here are consistent with correlations that have been made between gene expression and gene localisation in the mammalian nucleus either between cell types [9,10], or during differentiation [11].”
Recombination centres and the orchestration of V(D)J recombination (2011, background): “Considerable evidence now indicates that antigen receptor loci move away from these nuclear compartments when they undergo recombination and associate with them following the termination of recombinatio”
The nuclear pore complex: bridging nuclear transport and gene regulation (2010, background): “Association of chromatin with the nuclear envelope is generally thought to promote transcriptional repression, as heterochromatin or silenced loci can be found in association with the nuclear envelope across a diverse range of eukaryotic cell types, from budding yeast to avian erythrocyte”
Pax5: the guardian of B cell identity and function (2007, background): “However in wild-type pro-B cells, Pax5 induces large-scale contraction of the Igh locu”
Characterization of the Drosophila melanogaster genome at the nuclear lamina (2006, background): “For example, Ig loci move away from the nuclear envelope in B cells before their activation and genetic rearrangemen”
Molecular maps of the reorganization of genome – nuclear lamina interactions during differentiation (2010, background): “Fluorescence in situ hybridization (FISH) microscopy studies have suggested that certain genomic loci can move to or from the NL depending on the cell type (Kosak et al., 2002; Williams et al., 2006; Zink et al., 2004).”
A decade of 3C technologies: insights into nuclear organization. (2012, background): “positioning relative to the nuclear periphery and pericentromeric heterochromatin has been observed for some genes (most notably the imunnoglobulin and b-globin loci) (Kosak et al. 2002; Ragoczy et al. 2006).”
Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T‐cell receptor α/δ locus (2004, background): “Such restrictions are thought to be enforced, in large measure, by limiting access of the recombinase to RSSs within chromatin (1–3).”
Beyond the sequence: cellular organization of genome function. (2007, positive): “For example, the IgH locus is preferentially associated with the nuclear periphery in B cell progenitors where it is silent, but it moves toward the interior when it becomes potentiated in B cell precursors (Kosak et al., 2002; Ragoczy et al., 2006).”
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. (2006, background): “In non-B cells, however, both IgH loci are located at the nuclear periphery (134).”
Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions (2007, background): “Repositioning of the activated gene towards the nuclear interior has been documented for IgH (immunoglobulin heavy chain) in committed B lymphocyte”