Characterization of the Drosophila melanogaster genome at the nuclear lamina

By H. Pickersgill, B. Kalverda, E. D. Wit, W. Talhout, M. Fornerod, B. van Steensel. Nature Genetics, 2006

650 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/090966ed2544b61143ccdd32d09aee1436173f7c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. W. de Laat
2. E. de Wit
3. Job Dekker
4. Tom Misteli
5. B. Lajoie
6. Wendy A. Bickmore
7. Jop Kind
8. B. van Steensel

Citations in the corpus

• Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. (2008, neutral): “transcriptionally inactive DNA sequences in Drosophila (Pickersgill et al. 2006).”
• Mapping nucleosome resolution chromosome folding in yeast by Micro-C (2015, background): “, 2012), lamina-associated domains (LADs) (Pickersgill et al., 2006), and megabase-scale active and repressed chromatin compartments (Grob et al.”
• A decade of 3C technologies: insights into nuclear organization. (2012, methodology): “DamID (van Steensel and Henikoff 2000) is one such method that, when directed to proteins of the nuclear lamina, provides maps of chromatin associated with the nuclear periphery (Pickersgill et al. 2006).”
• Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery. (2012, positive): “To see whether H3K9me contributes to the peripheral localization of these endogenous domains, we applied lamin-DamID (Pickersgill et al., 2006) to probe their subnuclear position in wild-type and set-25 met-2 mutant worm embryos.”
• Single-cell dynamics of genome-nuclear lamina interactions. (2013, methodology): “This method was previously used to map genome-NL contacts (Guelen et al., 2008; Pickersgill et al., 2006).”
• Molecular maps of the reorganization of genome – nuclear lamina interactions during differentiation (2010, methodology): “Cell Identity and Gene Repression at the NL As a rule, NL-associated genes in all four mouse cell types have low transcriptional activity, similar to what has been observed in human and Drosophila cells (Guelen et al., 2008; Pickersgill et al., 2006).”
• Beyond the sequence: cellular organization of genome function. (2007, positive): “In Drosophila , defined genome regions containing clusters of closely spaced genes have been identified that preferentially associate with the periphery and whose expression is affected by this interaction (Pickersgill et al., 2006).”