ROS, mitochondria and the regulation of autophagy.

By R. Scherz-Shouval, Zvulun Elazar. Trends in Cell Biology, 2007

981 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Parasitology

View Paper: https://www.semanticscholar.org/paper/26abe369c83058355c9716ea67e2fb8890cece7a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. D. Tang
2. R. Kang
3. P. Boya
4. A. Andersson
5. H. J. Zeh
6. Michael Lotze
7. M. Bianchi
8. P. Westermark

In Molecular Biology

1. D. Tang
2. R. Kang
3. Michael Lotze
4. H. J. Zeh
5. Kevin J. Tracey
6. M. Bianchi
7. P. Boya
8. A. Andersson

In Parasitology

1. R. Kang
2. Alec C. Kimmelman
3. D. Tang

Citations in the corpus

• Regulation of superoxide dismutase genes: implications in disease. (2009, background): “However, excessive redox active species may cause DNA damage, repress the activity of cellular enzymes and induce cell death through activation of kinases and caspase cascades [5-8].”
• The dynamic nature of autophagy in cancer. (2011, background): “Additionally, the overexpression of p62 as a result of autophagy inhibition was shown to be important in the promotion of tumorigenesis through a variety of mechanisms, including deregulation of NF-kB signaling, accumulation of ROS, and increased DNA damage (Mathew et al. 2009). p62 contains a UBA d”
• Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis (2019, background): “ROS: Reactive oxygen species PUFAs: Polyunsaturated fatty acids NOXs: NADPH oxidases XO: Xanthine oxidase mETC: Mitochondrial electron-transport chain SOD: Superoxide dismutase CAT: Catalase HNE: Hydroxynonenal PL: Phospholipid LOX: Lipoxygenase Alox: Arachidonate lipoxygenase PLA2: Phospholipase A2”
• Cell Death Pathways in Photodynamic Therapy of Cancer (2011, background): “stimulate autophagy [118] that either acts in a cytoprotective manner or induces autophagic cell death [119].”
• The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance (2011, background): “As Vav-Atg7/ mice begin to develop (ROS; Scherz-Shouval and Elazar, 2007).”
• Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies (2017, background): “If this situation continues, mitochondrial bioenergetics and homeostasis are affected, resulting in cell death [14, 15].”
• Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging (2011, background): “It is generally accepted that ROS induce autophagy [125, 126], and that autophagy, in turn, serves to reduce oxidative damage [124].”
• Pathogenic Lysosomal Depletion in Parkinson's Disease (2010, background): “…accumulation of undegraded AP, which may be further enhanced by new AP formation in this pathological situation, in agreement with the known effects of mitochondrial dysfunction and ROS on autophagy induction (Scherz-Shouval and Elazar, 2007; Narendra et al., 2008; Vives-Bauza et al., 2010).”
• Endogenous HMGB1 regulates autophagy (2010, background): “The major source of endogenous ROS is the mitochondrial electron transport chain (mETC; ScherzShouval and Elazar, 2007).”
• Glutathione: new roles in redox signaling for an old antioxidant (2014, background): “However, under starvation cells increase production of mitochondrial-derived hydrogen peroxide, which has been shown to be partly dependent on the activation of class III PI3K (Scherz-Shouval and Elazar, 2007).”