Endogenous HMGB1 regulates autophagy

By D. Tang, R. Kang, K. Livesey, Chun-Wei Cheh, A. Farkas, P. Loughran, G. Hoppe, M. Bianchi, Kevin J. Tracey, H. J. Zeh and 1 more. Journal of Cell Biology, 2010

936 citations recorded by the source corpus.

HMGB1 displaces Bcl-2 from Beclin1 to induce and sustain autophagy in response to cell stress.

Subfields: Clinical Biochemistry, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8acb20a3357f60e3e6799d581147b3ce3048700a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. D. Tang
2. R. Kang
3. H. J. Zeh
4. Michael Lotze
5. Peter Vandenabeele
6. M. Bianchi
7. Xiao-Ming Yin
8. W. Ding

In Epidemiology

1. D. Tang
2. R. Kang
3. Michael Lotze
4. H. J. Zeh
5. N. Dupont
6. Sang Hun Lee
7. Manohar Pilli
8. M. Bianchi

In Molecular Biology

1. D. Tang
2. R. Kang
3. H. J. Zeh
4. Michael Lotze
5. Peter Vandenabeele
6. Sang Hun Lee
7. M. Bianchi
8. Xiao-Ming Yin

Citations in the corpus

• The Roles of Autophagy in Cancer (2018, background): “The basal level of autophagy operates as a mechanism for tumor suppression via reduction of damaged cellular parts and proteins and maintenance of cellular homeostasis [51].”
• The Beclin 1 network regulates autophagy and apoptosis (2011, neutral): “Recently, we have shown that HMGB1 is a novel Beclin 1-binding protein important in sustaining autophagy.(25,49) Deletion, depletion or inhibition of HMGB1 in mouse embryonic fibroblasts or tumor cells markedly diminishes autophagy.”
• Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β (2011, background): “This chromatin-associated nuclear protein (with addi- tional intracellular and extracellular signalling roles), upon exposure to inputs including those that induce autophagy (Singh et al, 2010; Tang et al, 2010), undergoes a complex set of biochemical and localization changes.”
• Immunogenic cell death and DAMPs in cancer therapy (2012, background): “These authors showed that a recombinant N-terminal fragment of CRT (39-272) is a potent inducer of activation and maturation of B cells and macrophages and can trigger Ig class switching in B cells without T cell help in vitro and in vivo72.”
• The Role of Autophagy in Cancer: Therapeutic Implications (2011, background): “Additionally, highmobility group box 1 (HMGB1) is an immune modulator and regulator of stress-induced autophagy that directly interacts with Beclin 1 (28).”
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “Autophagy, not apoptosis, is a major regulator of HMGB1 localization and release by ROS in the early events following cell stress (158, 159).”
• HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4 (2012, background): “Recently, it has emerged that the relocation of HMGB1 from the nucleus to the cytoplasm also controls autophagy and in turn autophagic cells can secrete HMGB1 (Livesey et al., 2009; Skinner, 2010; Tang et al., 2010).”