Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
By L. Su, Jiahao Zhang, H. Gómez, R. Murugan, X. Hong, Dongxue Xu, Fan Jiang, Z. Peng. Oxidative Medicine and Cellular Longevity, 2019
1,883 citations recorded by the source corpus.
Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental and conserved mechanism is based on an excess of ROS which attacks biomembranes, propagates lipid peroxidation chain reactions, and subsequently induces different types of cell death. A highly evolved sophisticated antioxidant system exists that acts to protect the cells from oxidative damage. In this review, we discussed how ROS propagate lipid peroxidation chain reactions and how the products of lipid peroxidation initiate apoptosis and autophagy in current models. We also discussed the mechanism of lipid peroxidation during ferroptosis, and we summarized lipid peroxidation in pathological conditions of critical illness. We aim to bring a more global and integrative sight to know how different ROS-induced lipid peroxidation occurs among apoptosis, autophagy, and ferroptosis.
Subfields: Biochemistry, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/43dfbe1f303c25565ed73936bc3818a9a9822091
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- H. Gómez
- Di Liu
- L. Su
- John A. Kellum
- Jiahao Zhang
- Siyuan Huang
- Jian-hui Sun
- Z. Peng
Citations in the corpus
- Mitochondria ROS and mitophagy in acute kidney injury (2022, background): “Thus, on the one hand, erastin targets the SLC7A11 receptor on membrane to influence the activity of GPX4 to induce ferroptosis.”
- Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options (2022, background): “For example, the proapoptotic protein Bim exacerbates apoptosis, while the antiapoptotic protein Bcl-2 inhibits apoptosis [31, 33].”