Biologically active sphingolipids in cancer pathogenesis and treatment

By B. Ogretmen, Yusuf A. Hannun. Nature Reviews. Cancer, 2004

1,269 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/25cc01578d74334d2b642dc1e194194066d50b38

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Citations in the corpus

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells (2009, positive): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript substrates to generate dihydroceramide or ceramide in the de novo or salvage pathway of sphingolipid synthesis, respectively (Ogretmen & Hannun, 2004).”
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. (2011, positive): “In addition to being important membrane lipids, sphingolipids play a role in signaling, as these lipids are implicated in cell growth, differentiation, senescence, apoptosis, and cancer (Futerman & Hannun 2004, Ogretmen & Hannun 2004).”
Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “16.3) (Ogretmen and Hannun, 2004).”
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer (2008, background): “The sphingolipids are a family of membrane lipids with important structural roles in the regulation of the fluidity and subdomain structure of the lipid bilayer [2].”
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing (2009, positive): “of their central role in cell signaling, and as potential drug targets for cancer and other human diseases, there is a great deal of interest in thesemolecules, and thus there is a corresponding level of interest in the regulation of the enzymes that are responsible for their synthesis and degradati”
Potentiation of cannabinoid-induced cytotoxicity in Mantle Cell Lymphoma through modulation of ceramide metabolism (2009, background): “(Mol Cancer Res 2009;7(7):1086–98) Introduction Ceramide accumulation is a widely described event in cancers after various treatments (1).”
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. (2007, background): “Although this might be a plausible possibility, whether C18-ceramide specifically plays a role in the activation of PP2A, and whether further metabolism of C18-ceramide into other complex lipids, might inhibit PP2A function, are still unknown.”
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. (2009, background): “We have previously shown that THC-induced accumulation of de novo–synthesized ceramide, an event that occurs in the ER (18), leads to upregulation of the stress-regulated protein p8 and its ER stress–related downstream targets, ATF4, CHOP, and TRB3, to induce cancer cell death (13).”
Molecular mechanisms of cancer development in obesity (2011, background): “Although alterations of sphingolipid metabolism may modulate tumorigenesi”
Cellular Fatty Acid Metabolism and Cancer (2013, background): “While sphingolipid metabolism is not a focus of this review, it is noteworthy that specific sphingolipids, such as ceramides and sphingosine-1-phosphate, are bioactive signaling molecules that generally suppress or promote tumors, respectively (Ogretmen and Hannun, 2004).”