Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular…

By S. Karahatay, Kesha L. Thomas, S. Koybasi, C. Senkal, Saeed, ElOjeimy, Xiang Liu, J. Bielawski, T. Day, M. B. Gillespie and 5 more. 2007

181 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. A. Futerman
2. Michal Levy
3. B. Ogretmen
4. Yusuf A. Hannun
5. C. Senkal
6. J. Bielawski
7. S. Saddoughi
8. P. Song

Citations in the corpus

• Mammalian Ceramide Synthases (2010, background): “Likewise, CerS1 plays an important role in the regulation of cell death in HNSCC cells via gemcitabine/doxorubicin-induced caspase activation (43).”
• Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells (2009, unknown): “Alterations in CerS1 and its product C18-ceramide have previously been reported to play a role in the regulation of HNSCC pathogenesis and therapy (Karahatay et al., 2007; Koybasi et al., 2004; Senkal et al., 2007), suggesting the possibility that other members of the CerS family play similar, yet…”
• C24‐Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5‐Phosphate 4‐Kinase Type‐2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation (2020, background): “Deletion of the segment (1-285) completely abolished the binding of PIP4K2C to C6-Ceramide.”
• Antiapoptotic roles of ceramide‐synthase‐6‐generated C16‐ceramide via selective regulation of the ATF6/ CHOP arm of ER‐stress‐response pathways (2010, background): “Our previous studies (3, 27, 28) have suggested that de novo-generated C18- and C16-ceramides play distinct roles in the regulation of cell death and/or the pathogenesis of HNSCCs.”
• Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “Interestingly, recent data (Koybasi et al., 2004; Karahatay et al., 2007) suggest while the levels of C18-ceramide are generally lower, C16-ceramide is significantly up-regulated in the majority (about 80”