Cellular Fatty Acid Metabolism and Cancer
By E. Currie, A. Schulze, R. Zechner, T. Walther, Robert V Farese. Cell Metabolism, 2013
1,919 citations recorded by the source corpus.
Cancer cells commonly have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a3972215a8a7b803f765a93fac45bb4cec0f0ec8
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In Cancer Research
- Nikos Koundouros
- W. Marston Linehan
- Matthew Meyerson
- Peter W. Laird
- Chad Creighton
- G. Poulogiannis
- Huafeng Zhang
- Zhaoyong Li
In Molecular Biology
- Hui Shen
- Angelika S. Rambold
- Peter W. Laird
- Nikos Koundouros
- Jennifer Lippincott-Schwartz
- W. Marston Linehan
- P. Park
- Michael Biehl
Citations in the corpus
- The somatic genomic landscape of chromophobe renal cell carcinoma (2014, background): “…and cancer-associated reprogramming of mitochondria and of other metabolic pathways, besides glycolysis and the Warburg effect, has recently received much attention (Currie et al., 2013; Ward , September 8, 2014 ª2014 Elsevier Inc. 9 Comprehensive Genomic Analysis of ChRCC and Thompson, 2012).”
- Reprogramming of fatty acid metabolism in cancer (2019, background): “These findings also point to a rationale for developing therapies targeting the tumour microenvironment through inhibition of adipocyte lipolysis, thereby reducing the availability of free lipids for cancer cells.(26) The uptake and scavenging of extracellular FAs also provides an important compensa”
- Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression (2015, background): “Fatty acids are required for energy storage, membrane synthesis and production of signaling molecules [72].”
- The Acidic Tumor Microenvironment as a Driver of Cancer. (2019, background): “Fatty acid metabolism is also profoundly altered in many cancers (72), and fatty acid oxidation has been found increased in acid-adapted cancer cells (42, 45).”
- Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies (2021, background): “Carnitine palmitoyltransferase 1A is the main regulator of FAO, which transfers fatty acids (FAs) from the cytoplasm to the mitochondria via the carnitine palmitoyl shuttle, where FAO occurs (Currie et al., 2013).”
- Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy and mitochondrial fusion dynamics (2015, background): “…cellular signaling cascades and contribute to FAdriven modulations in metabolism, inflammatory responses, and cell death programs (Calder, 2013; Wahli and Michalik, 2012; Zechner et al., 2012), alterations in their levels likely have huge health risks (Currie et al., 2013; Krahmer et al., 2013).”