Regulation of Longevity and Stress Resistance by Sch9 in Yeast

By P. Fabrizio, F. Pozza, S. Pletcher, C. Gendron, V. Longo. Science, 2001

882 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/22f06fd293bffb32235d3436a8adbd3363da71f3

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Citations in the corpus

mTOR: from growth signal integration to cancer, diabetes and ageing (2010, background): “Owing to its role at the interface of growth and starvation, mTOR is a prime target in the genetic control of ageing, and evidence from genetic studies supports the view that mTOR may be a master determinant of lifespan and ageing in yeas”
Replicative and Chronological Aging in Saccharomyces cerevisiae (2012, neutral): “These are the Tor/S6K pathway (Fabrizio et al., 2001), which is activatedby amino acids andother nutrients, and theRas/adenylate cyclase (AC)/PKA pathway (Longo et al., 1999, Fabrizio et al., 2003), which is principally activated by glucose, but also affected by other nutrients (Figure 2)…”
Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population (2014, neutral): “…and RAS-cAMP-PKA, promoted aging in multiple model organisms, thus providing evidence for the conserved regulation of aging by pro-growth nutrient signaling pathways (Fabrizio et al., 2001; Guarente and Kenyon, 2000; Kapahi and Zid, 2004; Kenyon, 2005, 2011; Longo, 1999; Tatar et al., 2001).”
With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging (2010, neutral): “, 2007), have been known to significantly extend life span (Fabrizio et al., 2001; Kaeberlein et al., 2005).”
Learning a hierarchical representation of the yeast transcriptomic machinery using an autoencoder model (2016, background): “As another example, a hidden node is mapped to both MSN2 and MSN4 [29], which belong to the same family and form hetero-dimers to regulate genes involved in general stress response.”
A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan (2015, background): “Surprisingly, the deletion of the serine threonine kinase Rim15, or of its downstream stress response transcription factors Msn2/4 and Gis1, well established to be important or essential for longevity extension by genetic and dietary interventions (Fabrizio et al., 2001; Wei et al., 2008), did not p”
Induction of autophagy by spermidine promotes longevity (2009, background): “Improved longevity often correlates with increased stress resistanc”
Sugar Sensing and Signaling in Plants Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.010455. (2002, background): “In yeast, Glc sensing and signaling pathways play a central role in longevity (Ashrafi et al., 2000; Lin et al., 2000; Fabrizio et al., 2001).”
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. (2004, background): “Sch9 is an AGC family kinase that possesses a C2 lipid-binding domain and is the closest yeast homolog of the metazoan pro-survival kinase Akt/PKB (Fabrizio et al. 2001; Jorgensen et al. 2002).”
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration (2002, background): “ROS do, however, limit the long-term survival of stationary phase yeast cell”