Replicative and Chronological Aging in Saccharomyces cerevisiae
By V. Longo, G. Shadel, Matt Kaeberlein, Brian K. Kennedy. Cell Metabolism, 2012
602 citations recorded by the source corpus.
Saccharomyces cerevisiae has directly or indirectly contributed to the identification of arguably more mammalian genes that affect aging than any other model organism. Aging in yeast is assayed primarily by measuring replicative or chronological lifespan. Here, we review the genes and mechanisms implicated in these two aging model systems and key remaining issues that need to be addressed to optimize these assays. Because of its well-characterized genome and proteome that is remarkably amenable to genetic manipulation and high-throughput screening procedures, S. cerevisiae will continue to serve as a leading model organism to study pathways relevant to human aging and disease.
Subfields: Aging, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/30559a821dbafd4d122f87748eef82845f3c075c
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In Aging
In Molecular Biology
Citations in the corpus
- Fasting: Molecular Mechanisms and Clinical Applications (2014, background): “These metabolic adaptations to fasting in mammals are reminiscent of those described earlier for E. coli and yeast, in which acetic acid accumulates in response to food deprivation (Gonidakis et al., 2010; Longo et al., 2012).”