RNA polymerase III transcribes human microRNAs

By G. Borchert, W. Lanier, B. Davidson. Nature Structural &Molecular Biology, 2006

1,487 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/22d24252e81e6abe30fd3c316ffe5eef26069020

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Citations in the corpus

Specialization and evolution of endogenous small RNA pathways (2007, background): “Finally, miRNAs in a cluster on human chromosome 19 (C19MC) are interspersed among Alu repeats and rely on promoters in these Alu elements for transcriptio”
Retrotransposons revisited: the restraint and rehabilitation of parasites. (2008, positive): “Analyzing a cluster of microRNA genes on human chromosome 19, Borchert et al. (2006) found some transcribed by upstream Alu Pol III promoters, as well as 50 others overlapping Alus and other repeats.”
Revisiting the principles of microRNA target recognition and mode of action (2009, background): “In the current molecular framework for miRNA biogenesis, primary (pri)-miRNA transcripts with stem-loop regions are usually produced by RNA polymerase II, but occasionally by RNA polymerase II”
microRNAs in cancer (2013, background): “DGCR8 is a double-stranded RNA–binding protein that recognizes the proximal ∼10 bp of the pri-miRNA hairpin stem, positioning the catalytic sites of the RNase III enzyme Drosha (18).”
Exporting RNA from the nucleus to the cytoplasm (2007, background): “The genes that encode miRNAs can be transcribed by either Pol II or Pol II”
Current prospects for RNA interference-based therapies (2011, background): “Primary microRNAs (pri-miRNAs) are transcribed by RNA polymerases [156] [157] [158] and are trimmed by the microprocessor complex (comprising Drosha and microprocessor complex subunit DCGR8) into ~70 nucleotide precursors, called pre-miRNAs 67, 159, 160 (left side of the figure).”
The impact of retrotransposons on human genome evolution (2009, neutral): “The functional promoter sequences of L1 and Alu elements can also initiate sense or antisense transcription through other gene”
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. (2007, neutral): “The canonical microRNA (miRNA) pathway converts primary hairpin precursor transcripts into 22 nucleotide regulatory RNAs via consecutive cleavages by two RNase III enzymes, Drosha and Dicer.”
A human snoRNA with microRNA-like functions. (2008, background): “Mole (pre-miRNAs) by the nuclear microprocessor complex containing the RNase III enzyme Drosha and its cofactor DGCR8 (Borchert et al., 2006; Denli et al., 2004; Gregory et al., 2004; Landthaler et al., 2004; Lee et al., 2003, 2004).”
Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “miRNA genes are transcribed by either RNA polymerase II or RNA polymerase III into primary miRNA transcripts (pri-miRNA”
Strategies for silencing human disease using RNA interference (2007, background): “34 ) in the nucleus (although a recent finding also describes miRNAs transcribed by RNA Pol III (Ref”