Strategies for silencing human disease using RNA interference

By Daniel H. Kim, John J. Rossi. Nature reviews genetics, 2007

1,098 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/71717336ee5628aded7b18ecac32cc59a4c318bd

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In Cancer Research

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Citations in the corpus

Current prospects for RNA interference-based therapies (2011, background): “In vitro synthesis of siRNAs using T7 polymerase creates 5′ triphosphates, which can induce type I interferon responses (type I IFN responses) 1 .”
RNA interference in the clinic: challenges and future directions (2010, background): “Additionally, once siRNAs are intracellular they only transiently cause gene silencing, as the concentration of the siRNAs decreases with each cell divisio”
Interfering with disease: a progress report on siRNA-based therapeutics (2007, background): “RNAi pathways are guided by small RNAs that include siRNAs and microRNAs (miRNAs), with the latter deriving from imperfectly paired non-coding hairpin RNA structures that are naturally transcribed by the genome 4, 5 .”
siRNA delivery systems for cancer treatment. (2009, background): “Several companies making siRNAs provide effective design algorithms online, which allow consideration of mRNA target sequence, secondary structure, and siRNA duplex end-stabilities, and also allow minimization of potential sequence-dependent off-target effects [15].”
The anaplastic lymphoma kinase in the pathogenesis of cancer (2008, background): “In vivo delivery of siRNA and ASO, however, is an unresolved technical issue that makes it difficult to predict whether they will ever be effective in lymphoma patient”
MicroRNA-directed transcriptional gene silencing in mammalian cells (2008, background): “Exogenous siRNAs have been shown to direct TGS of cancer and HIV-related genes in mammalian cells (24), and misregulation of endogenous miRNAs that target gene promoters may potentially play a role in the aberrant epigenetic silencing of cancerrelated genes, including genes that regulate apoptosis o”
Nanogels: an overview of properties, biomedical applications and obstacles to clinical translation (2015, background): “Some oligonucleotide-based therapies have already achieved significant success in clinical trials [117,118].”