Induction of phase I, II and III drug metabolism/transport by xenobiotics

By Changjiang Xu, C. Li, A. Kong. Archives of pharmacal research, 2005

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How researchers see this paper

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Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022, background): “Xenobiotic metabolism consists of phase I, phase II, and phase III enzymes involved in oxidation, conjugation/detoxification, and elimination, respectively [40,41].”
The aryl hydrocarbon receptor complex and the control of gene expression. (2008, background): “As such, a large number of AhR ligands can induce their own metabolism and clearance from the body by inducing drug-metabolizing enzymes of the phase I (oxidation) and phase II (conjugation), and transporters of the phase III (excretion) metabolic pathways.(117) Unfortunately, the metabolism of some”
Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials (2008, neutral): “The metabolizing enzyme systems can be classified as phase I and phase II, and in drug-metabolizing systems, some authors also include a phase III class of transporters (281).”
Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, background): “Coordinated up-regulation of drug-metabolizing enzymes and transporters is mediated by a number of hepatic transcription factors and has been discussed in greater detail in previous review articles (Handschin and Meyer, 2003; Klaassen and Slitt, 2005; Xu et al., 2005).”