Cooperation between complexes that regulate chromatin structure and transcription.

By G. Narlikar, Hua-Ying Fan, Robert E. Kingston. Cell, 2002

1,589 citations recorded by the source corpus.

Chromatin structure creates barriers for each step in eukaryotic transcription. Here we discuss how the activities of two major classes of chromatin-modifying complexes, ATP-dependent remodeling complexes and HAT or HDAC complexes, might be coordinated to create a DNA template that is accessible to the general transcription apparatus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2266873d739f2e5c44da97e7ea4c809ac188cb7e

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Citations in the corpus

Nuclear retinoid receptors and the transcription of retinoid-target genes. (2004, background): “…(SWI/SNF) which use the energy of ATP hydrolysis to reposition nucleosomes at the promoter through sliding them in cis or displacing them in trans, allowing the formation of nucleosome-free or nucleosome-spaced regions (Kingston and Narlikar, 1999; Vignali et al., 2000; Narlikar et al., 2002).”
The General Transcription Machinery and General Cofactors (2006, background): “, 2003) or by using the energy of ATP hydrolysis to alter histone-DNA contacts in a process known as chromatin remodeling (Narlikar et al., 2002).”
Ecdysone Control of Developmental Transitions: Lessons from Drosophila Research (2012, background): “Chromatin remodelers—Chromatin remodeling is a major epigenetic modification that uses ATP hydrolysis to alter histone-DNA contacts and thereby affect gene transcription (8, 79).”
Controlling the double helix (2003, background): “They are aided by chromatin-remodelling complexes that continually shuffle the positions of individual nucleosomes so that sites are randomly exposed for a fraction of tim”
β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation (2005, background): “, enzymes that maintain chromatin in a transcriptionally inactive stat”
Epigenetic regulation in psychiatric disorders (2007, neutral): “Several transcriptional activators contain intrinsic HAT activit”
Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. (2002, background): “…this filamentous fungus methylation can be caused by mutations in SWI2/SNF2-contains 5-methylcytosine ( 1.5 % of total C) concenlike proteins (see Narlikar et al., 2002 [this issue of Cell])trated in repetitive DNA (e.g., rRNA genes) and remnants in Arabidopsis, mice, and humans (Dennis et al.,…”
Rapid spontaneous accessibility of nucleosomal DNA (2005, background): “The ratio of equations (9) and (7) yields”
β-Catenin hits chromatin: regulation of Wnt target gene activation (2009, background): “and is a key modification in the coordination of transcriptional contro”
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. (2008, background): “Histone deactylases (HDACs) are another important component of heterochromatin (Narlikar et al., 2002).”
Genome-wide map of nucleosome acetylation and methylation in yeast. (2005, neutral): “Nucleosomes are thus critical to the organization and maintenance of genetic material, and their position and modification state can profoundly influence genetic activities such as regulation of gene expression (Kouzarides, 2002; Narlikar et al., 2002 ).”
The SANT domain: a unique histone-tail-binding module? (2004, background): “Two classes of highly conserved enzymes have been implicated as regulators of the accessibility of chromatin-packaged DN”
Elongation by RNA polymerase II: the short and long of it. (2004, background): “SWI/SNF (homothalic switching deficient/sucrose nonfermenting) is an ATP-dependent chromatin-remodeling complex previously recognized to have a role in transcription (Narlikar et al. 2002; Martens and Winston 2003).”